2H-Furo[2,3-f]indole-2-carboxylic acid, 8-chloro-3,5-dihydro-5-phenyl-, methyl ester

Base Information

Chemical Name:2H-Furo[2,3-f]indole-2-carboxylic acid, 8-chloro-3,5-dihydro-5-phenyl-, methyl ester
CAS No.:88062-26-4
Molecular Formula:C18H14ClNO3
Molecular Weight:327.767
Hs Code.:

Synonyms:

Suppliers and Price of 2H-Furo[2,3-f]indole-2-carboxylic acid, 8-chloro-3,5-dihydro-5-phenyl-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2H-Furo[2,3-f]indole-2-carboxylic acid, 8-chloro-3,5-dihydro-5-phenyl-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-Furo[2,3-f]indole-2-carboxylic acid, 8-chloro-3,5-dihydro-5-phenyl-, methyl ester

There total 16 articles about 2H-Furo[2,3-f]indole-2-carboxylic acid, 8-chloro-3,5-dihydro-5-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 591-50-4
iodobenzene

: 88062-25-3
8-chloro-3,5-dihydro-2H-furo<2,3-f>indole-2-carboxylic acid methyl ester

: 88062-26-4
8-chloro-3,5-dihydro-5-phenyl-2H-furo<2,3-f>indole-2-carboxylic acid methyl ester

Guidance literature:: With copper(I) bromide; sodium carbonate; In various solvent(s); at 170 ℃; for 5.5h;
DOI:10.1002/jhet.5570200443

Reference yield:

: 88062-27-5
2-Chlor-3-methyl-4-nitrophenol

: 88062-26-4
8-chloro-3,5-dihydro-5-phenyl-2H-furo<2,3-f>indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / NaHCO₃ / dimethylformamide / 12 h / 60 °C

2: 52 percent / diphenyl ether / 1 h / 225 - 230 °C

3: 72 percent / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 h / Ambient temperature

4: 41 percent / Jones reagent / acetone / 2 h

5: 95 percent / conc. H₂SO₄ / 1,2-dichloro-ethane / 1.5 h / Heating

6: dimethylformamide / 9 h / 160 - 163 °C

7: Fe powder / ethanol; acetic acid / 0.5 h / 80 - 85 °C

8: 68 percent / Cu₂Br₂, Na₂CO₃ / various solvent(s) / 5.5 h / 170 °C

With copper(I) bromide; jones reagent; sulfuric acid; iron; sodium hydrogencarbonate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In diphenylether; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.5570200443

Reference yield:

: 19183-03-0
2-chloro-6-nitro-3-hydroxybenzaldehyde

: 88062-26-4
8-chloro-3,5-dihydro-5-phenyl-2H-furo<2,3-f>indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 87 percent / K₂CO₃ / dimethylformamide / 6 h / 60 °C

2: 47 percent / diphenyl ether / 1 h / 225 - 230 °C

3: 64 percent / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 h / Ambient temperature

4: 1) NaOH; 2) CH₃COONa / 1) methanol, water, THF, 10 deg C, 1 h; 2) 140 deg C, 30 min.

5: 90 percent / conc. H₂SO₄ / methanol / 24 h / Ambient temperature

6: Jones reagent / acetone / 4 h

7: conc. H₂SO₄ / Ambient temperature; overnight

8: 65 percent / Fe powder / ethanol; acetic acid / 0.42 h

9: 68 percent / Cu₂Br₂, Na₂CO₃ / various solvent(s) / 5.5 h / 170 °C

With copper(I) bromide; sodium hydroxide; jones reagent; sulfuric acid; sodium acetate; iron; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; diphenylether; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.5570200443