Methyl 8-chloro-5-phenyl-5H-furo[2,3-F]indole-2-carboxylate

Base Information

Chemical Name:Methyl 8-chloro-5-phenyl-5H-furo[2,3-F]indole-2-carboxylate
CAS No.:88062-33-3
Molecular Formula:C18H12ClNO3
Molecular Weight:325.751
Hs Code.:
DSSTox Substance ID:DTXSID10521953
Wikidata:Q82386821

Synonyms:88062-33-3;DTXSID10521953;METHYL 8-CHLORO-5-PHENYL-5H-FURO[2,3-F]INDOLE-2-CARBOXYLATE

Suppliers and Price of Methyl 8-chloro-5-phenyl-5H-furo[2,3-F]indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 8-chloro-5-phenyl-5H-furo[2,3-F]indole-2-carboxylate

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:325.0505709
Heavy Atom Count:23
Complexity:454

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC2=CC3=C(C=CN3C4=CC=CC=C4)C(=C2O1)Cl

Technology Process of Methyl 8-chloro-5-phenyl-5H-furo[2,3-F]indole-2-carboxylate

There total 17 articles about Methyl 8-chloro-5-phenyl-5H-furo[2,3-F]indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 88062-26-4
8-chloro-3,5-dihydro-5-phenyl-2H-furo<2,3-f>indole-2-carboxylic acid methyl ester

: 88062-33-3
8-chloro-5-phenyl-5H-furo<2,3-f>indole-2-carboxylic acid methyl ester

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In benzene; for 6h; Heating;
DOI:10.1002/jhet.5570200443

Reference yield:

: 88062-27-5
2-Chlor-3-methyl-4-nitrophenol

: 88062-33-3
8-chloro-5-phenyl-5H-furo<2,3-f>indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / NaHCO₃ / dimethylformamide / 12 h / 60 °C

2: 52 percent / diphenyl ether / 1 h / 225 - 230 °C

3: 72 percent / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 h / Ambient temperature

4: 41 percent / Jones reagent / acetone / 2 h

5: 95 percent / conc. H₂SO₄ / 1,2-dichloro-ethane / 1.5 h / Heating

6: dimethylformamide / 9 h / 160 - 163 °C

7: Fe powder / ethanol; acetic acid / 0.5 h / 80 - 85 °C

8: 68 percent / Cu₂Br₂, Na₂CO₃ / various solvent(s) / 5.5 h / 170 °C

9: 81 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 6 h / Heating

With copper(I) bromide; jones reagent; sulfuric acid; iron; sodium hydrogencarbonate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diphenylether; ethanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1002/jhet.5570200443

Reference yield:

: 19183-03-0
2-chloro-6-nitro-3-hydroxybenzaldehyde

: 88062-33-3
8-chloro-5-phenyl-5H-furo<2,3-f>indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 87 percent / K₂CO₃ / dimethylformamide / 6 h / 60 °C

2: 47 percent / diphenyl ether / 1 h / 225 - 230 °C

3: 64 percent / 85percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 h / Ambient temperature

4: 1) NaOH; 2) CH₃COONa / 1) methanol, water, THF, 10 deg C, 1 h; 2) 140 deg C, 30 min.

5: 90 percent / conc. H₂SO₄ / methanol / 24 h / Ambient temperature

6: Jones reagent / acetone / 4 h

7: conc. H₂SO₄ / Ambient temperature; overnight

8: 65 percent / Fe powder / ethanol; acetic acid / 0.42 h

9: 68 percent / Cu₂Br₂, Na₂CO₃ / various solvent(s) / 5.5 h / 170 °C

10: 81 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / benzene / 6 h / Heating

With copper(I) bromide; sodium hydroxide; jones reagent; sulfuric acid; sodium acetate; iron; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; diphenylether; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1002/jhet.5570200443