tert-Butyl 5-methyl-2-(2-oxoazetidin-1-yl)benzoate

Base Information

Chemical Name:tert-Butyl 5-methyl-2-(2-oxoazetidin-1-yl)benzoate
CAS No.:88072-14-4
Molecular Formula:C15H19NO3
Molecular Weight:261.321
Hs Code.:
DSSTox Substance ID:DTXSID90539450
Wikidata:Q82415207

Synonyms:88072-14-4;tert-Butyl 5-methyl-2-(2-oxoazetidin-1-yl)benzoate;DTXSID90539450

Suppliers and Price of tert-Butyl 5-methyl-2-(2-oxoazetidin-1-yl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of tert-Butyl 5-methyl-2-(2-oxoazetidin-1-yl)benzoate

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:261.13649347
Heavy Atom Count:19
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)N2CCC2=O)C(=O)OC(C)(C)C

Technology Process of tert-Butyl 5-methyl-2-(2-oxoazetidin-1-yl)benzoate

There total 2 articles about tert-Butyl 5-methyl-2-(2-oxoazetidin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 88072-02-0
2-(3-Bromo-propionylamino)-5-methyl-benzoic acid tert-butyl ester

: 88072-14-4
5-Methyl-2-(2-oxo-azetidin-1-yl)-benzoic acid tert-butyl ester

Guidance literature:: With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

: 88071-89-0
5-Methyl-2-nitro-benzoic acid tert-butyl ester

: 88072-14-4
5-Methyl-2-(2-oxo-azetidin-1-yl)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / PtO₂, 80percent / methanol / 20 h / 25 °C / 735.5 Torr

2: 83 percent / 2,6-lutidine / benzene

3: 70 percent / NaH / dimethylformamide; CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; hydrogen; sodium hydride; platinum(IV) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;