(2E)-2-(quinolin-2-ylmethylidene)hydrazinecarbothioamide

Base Information

• Chemical Name: (2E)-2-(quinolin-2-ylmethylidene)hydrazinecarbothioamide
• CAS No.: 3608-81-9
• Molecular Formula: C11H10N4S
• Molecular Weight: 230.2889
• NSC Number: 79295
• ChEMBL ID: CHEMBL215065
• Mol file: 3608-81-9.mol

Synonyms:CHEMBL215065;3608-81-9;2-Formylquinoline thiosemicarbazone;NSC79295;(2E)-2-(quinolin-2-ylmethylidene)hydrazinecarbothioamide;BDBM50199450;NSC-79295;STK841136;AKOS005625219;[(E)-2-quinolylmethyleneamino]thiourea;NCGC00324159-01;1-(quinolin-2-ylmethylene)thiosemicarbazide;2-(quinolin-2-ylmethylene)hydrazinecarbothioamide;AB01320283-02

Chemical Property of (2E)-2-(quinolin-2-ylmethylidene)hydrazinecarbothioamide

Chemical Property:

• Vapor Pressure: 1.1E-07mmHg at 25°C
• Boiling Point: 432.6°Cat760mmHg
• Flash Point: 215.4°C
• Density: 1.33g/cm³
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 230.06261751
• Heavy Atom Count: 16
• Complexity: 279

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)C=NNC(=S)N
• Isomeric SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=N/NC(=S)N

Technology Process of (2E)-2-(quinolin-2-ylmethylidene)hydrazinecarbothioamide

There total 2 articles about (2E)-2-(quinolin-2-ylmethylidene)hydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.12%

quinoline 2-carbaldehyde (5470-96-2) + thiosemicarbazide (79-19-6) → 2‐(quinolin‐2‐ylmethylene)hydrazine carbothioamide (3608-81-9)

Guidance literature:

With acetic acid; In ethanol; for 10h; Reflux;

DOI:10.1016/j.ejmech.2011.07.003

Reference yield:

→ 2‐(quinolin‐2‐ylmethylene)hydrazine carbothioamide (3608-81-9)

Guidance literature:

2-Formylchinolin, Thiosemicarbazid;

Reference yield: 79.68%

2‐(quinolin‐2‐ylmethylene)hydrazine carbothioamide (3608-81-9) + 2,4-Dihydroxybenzaldehyde (95-01-2) → (2E,NE)-N-(2,4-dihydroxybenzylidene)-2-(quinolin-2-ylmethylene)hydrazinecarbothioamide

Guidance literature:

In ethanol; for 5h; Reflux;

upstream raw materials:

quinoline 2-carbaldehyde

thiosemicarbazide