4-[5-(4-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine

Base Information

Chemical Name:4-[5-(4-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine
CAS No.:88085-28-3
Molecular Formula:C₁₄H₁₁N₃O₂
Molecular Weight:253.26
Hs Code.:
DSSTox Substance ID:DTXSID30355035
Wikidata:Q82133631
ChEMBL ID:CHEMBL1334030

Synonyms:88085-28-3;4-[5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine;methyl 4-[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]phenyl ether;5-(4-methoxyphenyl)-3-pyridin-4-yl-1,2,4-oxadiazole;Oprea1_579801;Oprea1_819145;MLS001165189;CHEMBL1334030;SCHEMBL13416230;DTXSID30355035;HMS2881J06;STK117848;AKOS000643192;8K-559S;SMR000549726;CS-0302769;SR-01000501769;SR-01000501769-1;Z57683961;5-(4-Methoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole

Suppliers and Price of 4-[5-(4-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-[5-(4-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine

Chemical Property:

Boiling Point:445.6±55.0 °C(Predicted)
PSA：61.04000
Density:1.226±0.06 g/cm3(Predicted)
LogP:2.80720
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:253.085126602
Heavy Atom Count:19
Complexity:276

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NC(=NO2)C3=CC=NC=C3

Technology Process of 4-[5-(4-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine

There total 4 articles about 4-[5-(4-Methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 63824-99-7
4-Methoxy-N-pyridin-4-ylmethyl-benzamide

: 88085-28-3
5-(4-methoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole

Guidance literature:: With nitrosylchloride; In chloroform; Ambient temperature; overnight;
DOI:10.1002/jhet.5570200548

Reference yield:

: C₁₄H₁₃N₃O₂

: 88085-28-3
5-(4-methoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole

Guidance literature:: With hydroxylamine hydrochloride; acetic acid; at 80 ℃; for 3.5h;
DOI:10.1039/c4nj00361f

Reference yield:

: 6345-27-3,42518-06-9,61875-64-7
4-amidinopyridine hydrochloride

: 100-09-4
4-methoxybenzoic acid

: 88085-28-3
5-(4-methoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2: hydroxylamine hydrochloride; acetic acid / 3.5 h / 80 °C

With hydroxylamine hydrochloride; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1039/c4nj00361f