Epothilone C

Base Information

Chemical Name:Epothilone C
CAS No.:186692-73-9
Molecular Formula:C26H39 N O5 S
Molecular Weight:477.665
Hs Code.:
UNII:18T00XLN7E
Nikkaji Number:J1.005.243B,J1.186.303E
Wikidata:Q27149174
Metabolomics Workbench ID:104429
ChEMBL ID:CHEMBL319648
Mol file:186692-73-9.mol

Synonyms:epothilone C

Suppliers and Price of Epothilone C

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 20 raw suppliers

Chemical Property of Epothilone C

Chemical Property:

Boiling Point:657.7±55.0 °C(Predicted)
PKA:13.47±0.70(Predicted)
PSA：124.96000
Density:1.097
LogP:5.26630
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:477.25489452
Heavy Atom Count:33
Complexity:734

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCCC=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C
Isomeric SMILES:C[C@H]1CCC/C=C\C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C2=CSC(=N2)C)/C
Uses Epothilone C is a related compound of Epothilones, which are a novel class of antineoplastic agents with antitubulin activity. In addition, Epothilones utilize a similar mechanism of action to that of taxanes and are less susceptible to multidrug resistance caused by P-glycoprotein. Studies showed that Epothilones exhibit antitumor activity against human cancer cells that are taxane-resistant.

Technology Process of Epothilone C

There total 224 articles about Epothilone C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 186692-84-2
(4S,7R,8S,9S,16S)-4,8-bis-(tert-butyldimethylsilanyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)-1-vinyl]-(13Z)-1-oxacyclohexadec-13-ene-2,6-dione

: 186692-73-9
desoxyepothilone A

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; Ambient temperature;

Reference yield: 98.0%

: 187283-49-4
(Z)-(4S,7R,8S,9S,16S)-4-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione

: 186692-73-9
desoxyepothilone A

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1002/anie.199701661

Reference yield: 88.0%

: 479485-01-3
(Z)-(4S,7R,8S,9S,16S)-8-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione

: 186692-73-9
desoxyepothilone A

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1002/1521-3765(20020816)8:16<3717::AID-CHEM3717>3.0.CO;2-G