L-Serine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 2-phenyl-2-[1-(phenylmethyl)-1H-tetrazol-5-yl]hydrazide

Base Information

Chemical Name:L-Serine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 2-phenyl-2-[1-(phenylmethyl)-1H-tetrazol-5-yl]hydrazide
CAS No.:88104-52-3
Molecular Formula:C29H33N7O4
Molecular Weight:543.626
Hs Code.:

Synonyms:

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Chemical Property of L-Serine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 2-phenyl-2-[1-(phenylmethyl)-1H-tetrazol-5-yl]hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of L-Serine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 2-phenyl-2-[1-(phenylmethyl)-1H-tetrazol-5-yl]hydrazide

There total 1 articles about L-Serine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 2-phenyl-2-[1-(phenylmethyl)-1H-tetrazol-5-yl]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1676-75-1
N-benzyloxycarbonyl-O-t-butyl-L-serine

: 88104-39-6
1-phenyl-1-(1-benzyl-1H-tetrazol-5-yl)hydrazine hydrobromide

: 88104-52-3
benzyl -2-t-butoxyethyl>carbamate

Guidance literature:: With 1,1'-carbonyldiimidazole; In 1,2-dichloro-ethane; at 82 ℃; for 63h; Heating;
DOI:10.1016/S0040-4020(01)92153-2

Reference yield:

: 88104-52-3
benzyl -2-t-butoxyethyl>carbamate

: (S)-3-Amino-1-[(1-benzyl-1H-tetrazol-5-yl)-phenyl-amino]-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1) trifluoroacetic acid, R_.T_., 6 h; 2) CH₂Cl₂, Et₃N

2: 74 percent / Ph₃P, dimethyl azodicarboxylate / CH₂Cl₂ / 48 h / Ambient temperature

3: H₂ / 10percent Pd-C / methanol / 2 h

With hydrogen; dimethyl azodicarboxylate; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)92153-2

Reference yield:

: 88104-52-3
benzyl -2-t-butoxyethyl>carbamate

: 88105-30-0
2(S)-amino-3-hydoxy-N-<2-oxo-1-<(phenyl)(1H-tetrazol-5-yl)amino>-3(S)-azetidinyl>propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) trifluoroacetic acid, R_.T_., 6 h; 2) CH₂Cl₂, Et₃N

2: 74 percent / Ph₃P, dimethyl azodicarboxylate / CH₂Cl₂ / 48 h / Ambient temperature

3: H₂ / 10percent Pd-C / methanol / 2 h

4: Et₃N / dimethylformamide

5: 0.007 g / H₂ / 10percent Pd-C / methanol; H₂O / 4 h

With hydrogen; dimethyl azodicarboxylate; triethylamine; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)92153-2