Benzenesulfonamide, 4-methyl-N-[1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-, (S)-

Base Information

• Chemical Name: Benzenesulfonamide, 4-methyl-N-[1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-, (S)-
• CAS No.: 88129-44-6
• Molecular Formula: C17H21NO5S2
• Molecular Weight: 383.489

Synonyms:(S)-N,O-ditosylalaninol;4-Methyl-N-[(1S)-1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]benzenesulfonamide;(S)-2-(4-methylbenzenesulfonamido)propyl 4-methylbenzenesulfonate;(2S)-O-(p-toluenesulfonyl)-N-(p-toluenesulfonyl)alaninol;

Chemical Property of Benzenesulfonamide, 4-methyl-N-[1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-, (S)-

Chemical Property:

• Melting Point: 96-98 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 549.8±60.0 °C(Predicted)
• PSA: 106.30000
• Density: 1.284±0.06 g/cm3(Predicted)
• LogP: 4.92820

Purity/Quality:

4-Methyl-N-[(1S)-1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methyl-N-[(1S)-1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]benzenesulfonamide is an intermediate in the synthesis of chiral annulet of 1,4,7-triazacyclononanes.

Technology Process of Benzenesulfonamide, 4-methyl-N-[1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-, (S)-

There total 6 articles about Benzenesulfonamide, 4-methyl-N-[1-methyl-2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-Alaninol (2749-11-3) + p-toluenesulfonyl chloride (98-59-9) → (S)-N-(p-toluenesulfonyl)-2-amino-1-propyl p-toluenesulfonate (88129-44-6)

Guidance literature:

With pyridine;

DOI:10.1016/S0040-4039(02)00705-0

Reference yield: 84.0%

(S)-2-(toluene-4-sulfonamido)propan-1-ol (100132-60-3,114663-10-4,139758-16-0) + p-toluenesulfonyl chloride (98-59-9) → (S)-N-(p-toluenesulfonyl)-2-amino-1-propyl p-toluenesulfonate (88129-44-6)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1002/ejoc.201800517

Reference yield: 80.0%

(R)-2-aminopropan-1-ol (35320-23-1) + p-toluenesulfonyl chloride (98-59-9) → Toluene-4-sulfonic acid (R)-2-(toluene-4-sulfonylamino)-propyl ester (88129-44-6)

Guidance literature:

In pyridine; at 0 ℃;

DOI:10.1016/S0040-4039(00)88062-4

upstream raw materials:

(R)-2-aminopropan-1-ol

p-toluenesulfonyl chloride

(S)-Alaninol

(S)-2-(toluene-4-sulfonamido)propan-1-ol

Downstream raw materials:

[(R)-2-(Toluene-4-sulfonylamino)-propyl]-phosphonic acid diethyl ester

Methyl-[(R)-2-(toluene-4-sulfonylamino)-propyl]-phosphinic acid ethyl ester

S-(+)-2-methyl-N-p-tosylaziridine

methyl (S,2E)-6-aza-10-bromo-5-methyl-6-(p-toluenesulfonyl)deca-2,8-dienoate

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