Technology Process of 2-Azetidinone,
4-[2,2-bis(methylthio)-2-phenylethyl]-1-[(1,1-dimethylethyl)dimethylsilyl]-,
(S)-
There total 1 articles about 2-Azetidinone,
4-[2,2-bis(methylthio)-2-phenylethyl]-1-[(1,1-dimethylethyl)dimethylsilyl]-,
(S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
n-butyllithium;
Yield given. Multistep reaction;
1) THF, hexane, -23 deg C -> -20 deg C, 1 h, 2) THF, 1 h, -78 deg C -> 0 deg C, 1 h;
DOI:10.1016/S0040-4020(01)92147-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 98 percent / HgO, HgCl2 / methanol / 0.5 h / Ambient temperature
2: 81 percent / MeOH, H2O, 1 N HCl / tetrahydrofuran / 15 h / Ambient temperature
3: 77 percent / toluene / 8 h / Heating
4: 96 percent / thionylchloride, Amberlyst A21 / CH2Cl2 / 3 h / -18 deg C -> 0 deg C
5: 2) 5percent NaHCO3 aq / dimethylformamide / 19 h / 2 °C
With
hydrogenchloride; methanol; thionyl chloride; amberlyst A21; water; sodium hydrogencarbonate; mercury dichloride; mercury(II) oxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)92147-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 98 percent / HgO, HgCl2 / methanol / 0.5 h / Ambient temperature
2: 81 percent / MeOH, H2O, 1 N HCl / tetrahydrofuran / 15 h / Ambient temperature
With
hydrogenchloride; methanol; water; mercury dichloride; mercury(II) oxide;
In
tetrahydrofuran; methanol;
DOI:10.1016/S0040-4020(01)92147-7
