2-Octenoic acid, 7-[(chloroacetyl)oxy]-4,8-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2Z,4R,7R)-

Base Information

Chemical Name:2-Octenoic acid, 7-[(chloroacetyl)oxy]-4,8-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2Z,4R,7R)-
CAS No.:881663-85-0
Molecular Formula:C57H71ClO6Si2
Molecular Weight:943.811
Hs Code.:

2-Octenoic acid,
7-[(chloroacetyl)oxy]-4,8-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-,
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2Z,4R,7R)-

Synonyms:

Suppliers and Price of 2-Octenoic acid, 7-[(chloroacetyl)oxy]-4,8-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2Z,4R,7R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Octenoic acid, 7-[(chloroacetyl)oxy]-4,8-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2Z,4R,7R)-

Chemical Property:

Purity/Quality:

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Technology Process of 2-Octenoic acid, 7-[(chloroacetyl)oxy]-4,8-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2Z,4R,7R)-

There total 4 articles about 2-Octenoic acid, 7-[(chloroacetyl)oxy]-4,8-bis[[(1,1-dimethylethyl)diphenylsilyl]oxy]-, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2Z,4R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 79-11-8
chloroacetic acid

: 837428-23-6
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl (2Z,4R,7S)-4,8-bis{[tert-butyl(diphenyl)silyl]oxy}-7-hydroxyoct-2-enoate

: 881663-85-0
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl (2Z,4R,7R)-4,8-bis-{[tert-butyl(diphenyl)silyl]oxy}-7-[(chloroacetyl)oxy]oct-2-enoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In toluene; at 20 ℃; for 3h;
DOI:10.1021/ol0479242

Reference yield:

: 134341-56-3
meso-(2R,5S)-2,5-bis(tert-butyldiphenylsilyloxy)hexane-1,6-dial

: 881663-85-0
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl (2Z,4R,7R)-4,8-bis-{[tert-butyl(diphenyl)silyl]oxy}-7-[(chloroacetyl)oxy]oct-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / NaHMDS / tetrahydrofuran; toluene / 4 h / -78 °C

2: NaBH₄ / tetrahydrofuran; propan-2-ol / 3 h / 0 °C

3: DMAP / ethanol; various solvent(s) / 14 h / Heating

4: 95 percent / PPh₃; DIAD / toluene / 3 h / 20 °C

With dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; ethanol; isopropyl alcohol; toluene; 1: Horner-Wadsworth-Emmons reaction / 4: Mitsunobu reaction;
DOI:10.1021/jo052233k

Reference yield:

: 837428-48-5
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl (2Z,4R,7S)-4,8-bis{[tert-butyl(diphenyl)silyl]oxy}-8-oxooct-2-enoate

: 881663-85-0
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl (2Z,4R,7R)-4,8-bis-{[tert-butyl(diphenyl)silyl]oxy}-7-[(chloroacetyl)oxy]oct-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / tetrahydrofuran; propan-2-ol / 3 h / 0 °C

2: DMAP / ethanol; various solvent(s) / 14 h / Heating

3: 95 percent / PPh₃; DIAD / toluene / 3 h / 20 °C

With dmap; sodium tetrahydroborate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethanol; isopropyl alcohol; toluene; 3: Mitsunobu reaction;
DOI:10.1021/jo052233k