Methyl 4-amino-3-(benzyloxy)-5-bromobenzenecarboxylate

Base Information

• Chemical Name: Methyl 4-amino-3-(benzyloxy)-5-bromobenzenecarboxylate
• CAS No.: 881909-58-6
• Molecular Formula: C15H14BrNO3
• Molecular Weight: 336.185
• Hs Code.: 2922509090
• Mol file: 881909-58-6.mol

Synonyms:HD-0055;methyl 4-amino-3-bromo-5-[(phenylmethyl)oxy]benzoate;methyl 4-amino-3-benzyloxy-5-bromobenzoate;

Chemical Property of Methyl 4-amino-3-(benzyloxy)-5-bromobenzenecarboxylate

Chemical Property:

• Melting Point: 84-86°
• PSA: 61.55000
• LogP: 3.97810

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 4-amino-3-(benzyloxy)-5-bromobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-amino-3-(benzyloxy)-5-bromobenzenecarboxylate

There total 6 articles about Methyl 4-amino-3-(benzyloxy)-5-bromobenzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 4-amino-3-(benzyloxy)benzoate (475215-88-4) → methyl 4-amino-3-benzyloxy-5-bromobenzoate (881909-58-6)

Guidance literature:

With bromine; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

methyl 3-(benzyloxy)-4-nitrobenzoate (209528-69-8) → methyl 4-amino-3-benzyloxy-5-bromobenzoate (881909-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Fe; AcOH / 3 h / 20 - 50 °C

2: Br₂ / CH₂Cl₂ / 0.25 h / 20 °C

With bromine; iron; acetic acid; In dichloromethane;

DOI:10.1055/s-2006-950223

Reference yield:

methyl 3-hydroxy-4-nitrobenzoate (713-52-0) → methyl 4-amino-3-benzyloxy-5-bromobenzoate (881909-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 5 h / Heating

2: Fe; AcOH / 3 h / 20 - 50 °C

3: Br₂ / CH₂Cl₂ / 0.25 h / 20 °C

With bromine; iron; potassium carbonate; acetic acid; In dichloromethane; acetone;

DOI:10.1055/s-2006-950223

upstream raw materials:

methyl 4-amino-3-(benzyloxy)benzoate

methyl 3-(benzyloxy)-4-nitrobenzoate

methyl 3-hydroxy-4-nitrobenzoate

benzyl bromide

Downstream raw materials:

methyl 3-ethyl-7-[(phenylmethyl)oxy]-1H-indole-5-carboxylate

methyl 3-bromo-4-[(2E,Z)-2-buten-1-yl(trifluoroacetyl)amino]-5-[(phenylmethyl)oxy]benzoate

methyl 3-benzyloxy-5-bromo-4-[(trifluoroacetyl)amino]benzoate