2-Propenoic acid, 3-[2-(1-cyclohexen-1-yl)-8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carb onyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-

Base Information

Chemical Name:2-Propenoic acid, 3-[2-(1-cyclohexen-1-yl)-8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carb onyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-
CAS No.:881997-23-5
Molecular Formula:C29H34N4O4S
Molecular Weight:534.679
Hs Code.:

2-Propenoic acid,
3-[2-(1-cyclohexen-1-yl)-8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carb
onyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester,
(2E)-

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Chemical Property of 2-Propenoic acid, 3-[2-(1-cyclohexen-1-yl)-8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carb onyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-

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Technology Process of 2-Propenoic acid, 3-[2-(1-cyclohexen-1-yl)-8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carb onyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)-

There total 4 articles about 2-Propenoic acid, 3-[2-(1-cyclohexen-1-yl)-8-[[[4-(1,1-dimethylethyl)-2-thiazolyl]amino]carb onyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-, 1,1-dimethylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 881997-21-3
methyl 3-[(1E)-3-tert-butoxy-3-oxoprop-1-enyl]-2-(cyclohex-1-enyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylate

: 74370-93-7
2-amino-4-tert-butylthiazole

: 881997-23-5
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(cyclohex-1-enyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2005.10.043

Reference yield:

: 881997-02-0
methyl 2-chloro-3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylate

: 881997-23-5
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(cyclohex-1-enyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / tetrahydrofuran; dimethylformamide / 47 h

2: 250 mg / 2,6-di-tert-butyl-p-cresol / Pd(PPh₃)4 / dimethylformamide / Heating

3: 84 percent / ethyldiisopropylamine; N,N-bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride / CH₂Cl₂

With 2,6-di-tert-butyl-4-methyl-phenol; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Wittig-Horner reaction / 2: Stille coupling;
DOI:10.1016/j.bmc.2005.10.043

Reference yield:

: 881997-03-1
methyl 3-[(1E)-3-tert-butoxy-3-oxoprop-1-enyl]-2-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-8-carboxylate

: 881997-23-5
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(cyclohex-1-enyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 250 mg / 2,6-di-tert-butyl-p-cresol / Pd(PPh₃)4 / dimethylformamide / Heating

2: 84 percent / ethyldiisopropylamine; N,N-bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride / CH₂Cl₂

With 2,6-di-tert-butyl-4-methyl-phenol; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; 1: Stille coupling;
DOI:10.1016/j.bmc.2005.10.043