(1S,2R)-2-BenzylaMino-1-cyclohexanol

Base Information

Chemical Name:(1S,2R)-2-BenzylaMino-1-cyclohexanol
CAS No.:882409-10-1
Molecular Formula:C13H19NO
Molecular Weight:205.3
Hs Code.:
Mol file:882409-10-1.mol

Synonyms:(1S,2R)-2-(benzylamino)cyclohexanol;(1S,2R)-2-Benzylamino-cyclohexanol;(1S,2R)-2-benzylaminocyclohexanol;

Suppliers and Price of (1S,2R)-2-BenzylaMino-1-cyclohexanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (1S,2R)-2-BenzylaMino-1-cyclohexanol

Chemical Property:

Melting Point:51-53 °C
Boiling Point:339.2±35.0 °C(Predicted)
PKA:14.83±0.40(Predicted)
PSA：32.26000
Density:1.06±0.1 g/cm3(Predicted)
LogP:2.47060

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1S,2R)-2-BenzylaMino-1-cyclohexanol

There total 4 articles about (1S,2R)-2-BenzylaMino-1-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 141478-34-4
1-(N-benzylamino)-2-cyclohexanone

: 882409-10-1
(1S,2R)-cis-2-(N-benzyl)amino-1-cyclohexanol

Guidance literature:: With RuCl₂[(S)-XylSDP][(R,R)-DPEN]; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 20 ℃; for 18h; under 7600.51 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;
DOI:10.1021/ol901605a

Reference yield:

: (3aR,7aS)-3-benzyl-3a,4,5,6,7,7a-hexahydro-1,3-benzoxazol-2(3H)-one

: 882409-10-1
(1S,2R)-cis-2-(N-benzyl)amino-1-cyclohexanol

Guidance literature:: With potassium hydroxide; In ethanol; water; at 60 ℃; for 72h;
DOI:10.1021/ol0491080

Reference yield:

: 141553-09-5
(1R,2R)-trans-2-(N-benzyl)amino-1-cyclohexanol

: 882409-10-1
(1S,2R)-cis-2-(N-benzyl)amino-1-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: DBU / acetonitrile / 0.75 h / 20 °C

1.2: 69 percent / n-Bu₃P; di-tert-butyl azodicarboxylate / acetonitrile / 0.33 h / 0 °C

2.1: KOH / ethanol; H₂O / 72 h / 60 °C

With potassium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; water; acetonitrile; 1.2: Mitsunobu reaction;
DOI:10.1021/ol0491080