(2R,3R)-3-(4-chlorophenyl)aziridine-2-carboxamide

Base Information

Chemical Name:(2R,3R)-3-(4-chlorophenyl)aziridine-2-carboxamide
CAS No.:88286-08-2
Molecular Formula:C₉H₉ClN₂O
Molecular Weight:196.636
Hs Code.:
DSSTox Substance ID:DTXSID60525305
Wikidata:Q82392808

Synonyms:DTXSID60525305;88286-08-2;(2R,3R)-3-(4-chlorophenyl)aziridine-2-carboxamide

Suppliers and Price of (2R,3R)-3-(4-chlorophenyl)aziridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (2R,3R)-3-(4-chlorophenyl)aziridine-2-carboxamide

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:196.0403406
Heavy Atom Count:13
Complexity:214

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2C(N2)C(=O)N)Cl
Isomeric SMILES:C1=CC(=CC=C1[C@@H]2[C@@H](N2)C(=O)N)Cl

Technology Process of (2R,3R)-3-(4-chlorophenyl)aziridine-2-carboxamide

There total 7 articles about (2R,3R)-3-(4-chlorophenyl)aziridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1552-70-1,14776-73-9,14737-97-4
(Z)-methyl 3-(4-chlorophenyl)-2-chloropropenoate

: 88286-08-2,133474-09-6
trans-2-(4-chlorophenyl)aziridine-3-carboxylic acid amide

Guidance literature:: With ammonia; at 65 ℃; for 24h;
DOI:10.1021/jo00010a027

Reference yield: 60.0%

: 88286-04-8
(2S,3S)-3-(4-Chloro-phenyl)-aziridine-2-carbonitrile

: 88286-08-2,133474-09-6
(2R,3R)-3-(4-Chloro-phenyl)-aziridine-2-carboxylic acid amide

Guidance literature:: With potassium hydroxide; In ethanol; water; for 168h; Ambient temperature;

Reference yield:

: 133474-01-8
1-(4-chlorophenyl)-2,3,3-trichloro-1-oxopropene

: 88286-08-2,133474-09-6
trans-2-(4-chlorophenyl)aziridine-3-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / ethanol

2: 1) H₂SO₄, 2) water / 1) 105 deg C, 45 min, 2) 30 min

3: 84 percent / NH₃(liq.) / 24 h / 65 °C

With sodium tetrahydroborate; sulfuric acid; ammonia; water; In ethanol;
DOI:10.1021/jo00010a027