Ophthalmic acid

Base Information

Chemical Name:Ophthalmic acid
CAS No.:495-27-2
Deprecated CAS:30631-43-7
Molecular Formula:C₁₁H₁₉N₃O₆
Molecular Weight:289.288
Hs Code.:
UNII:3A60475Q1Q
DSSTox Substance ID:DTXSID40895053
Nikkaji Number:J15.204H
Wikipedia:Ophthalmic_acid
Wikidata:Q7098084
Metabolomics Workbench ID:38741
Mol file:495-27-2.mol

Synonyms:gamma-Glu-alpha-aminobutyryl-Gly;ophthalmic acid

Suppliers and Price of Ophthalmic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Ophthalmic Acid
5mg
$ 396.00

American Custom Chemicals Corporation
H-GAMMA-GLU-ABU-GLY-OH 95.00%
25MG
$ 580.00

American Custom Chemicals Corporation
H-GAMMA-GLU-ABU-GLY-OH 95.00%
5MG
$ 460.00

AK Scientific
Ophthalmicacid
100mg
$ 299.00

AK Scientific
Ophthalmicacid
25mg
$ 178.00

Total 21 raw suppliers

Chemical Property of Ophthalmic acid

Chemical Property:

Vapor Pressure:3.38E-22mmHg at 25°C
Melting Point:177-179 °C (decomp)
Boiling Point:560.2°Cat760mmHg
PKA:2.22±0.10(Predicted)
Flash Point:292.6°C
PSA：165.80000
Density:1.384g/cm³
LogP:0.65500
Storage Temp.:-15°C
XLogP3:-3.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:289.12738533
Heavy Atom Count:20
Complexity:384

Purity/Quality:

98%Min ^*data from raw suppliers

Ophthalmic Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
Isomeric SMILES:CC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
Uses Ophthalmic Acid is used in the composition and method for enhancing cooling sensation of food and beverage, and flavor composition.

Technology Process of Ophthalmic acid

There total 15 articles about Ophthalmic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

: (S)-2-Benzyloxycarbonylamino-4-[(S)-1-(benzyloxycarbonylmethyl-carbamoyl)-propylcarbamoyl]-butyric acid benzyl ester

: 82153-39-7,495-27-2
Ophthalmic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

: 3705-42-8
Cbz-(L)-Glu-OBn

: 82153-39-7,495-27-2
Ophthalmic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 56.14 percent / TEA, hydroxysuccinimide, DCCI / tetrahydrofuran / 24 h

2: 76.5 percent / H₂ / Pd/C / methanol

With 1-hydroxy-pyrrolidine-2,5-dione; TEA; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol;

Reference yield:

: 16305-80-9
L-α-Amino-butyryl-glycin

: 82153-39-7,495-27-2
Ophthalmic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; KHCO₃; H₂O

2: palladium; aqueous acetic acid / Hydrogenation

With diethyl ether; water; potassium hydrogencarbonate; palladium; acetic acid;