5-ISOBUTYL-[1,3,4]THIADIAZOL-2-YLAMINE

Base Information

• Chemical Name: 5-ISOBUTYL-[1,3,4]THIADIAZOL-2-YLAMINE
• CAS No.: 52057-89-3
• Molecular Formula: C₆H₁₁N₃S
• Molecular Weight: 157.239
• Hs Code.: 2934999090
• Mol file: 52057-89-3.mol

Synonyms:2-amino-5-isobutyl-1,3,4-thiadiazole;5-isobutyl-1,3,4-thiadiazol-2-amine;2-Amino-5-isobutyl-1,3,4-thiadiazol;

Chemical Property of 5-ISOBUTYL-[1,3,4]THIADIAZOL-2-YLAMINE

Chemical Property:

• Vapor Pressure: 0.00371mmHg at 25°C
• Boiling Point: 280.8°Cat760mmHg
• Flash Point: 123.6°C
• PSA: 80.04000
• Density: 1.174g/cm³
• LogP: 1.90000

Purity/Quality:

97% ^*data from raw suppliers

5-Isobutyl-[1,3,4]thiadiazol-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ISOBUTYL-[1,3,4]THIADIAZOL-2-YLAMINE

There total 5 articles about 5-ISOBUTYL-[1,3,4]THIADIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

thiosemicarbazide (79-19-6) + isopentanoyl chloride (108-12-3) → 2-amino-5-isobutyl-1,3,4-thiadiazole (52057-89-3) + N-(isobutyl-[1,3,4]thiadiazol-2-yl)-isovaleramide (331819-06-8)

Guidance literature:

at 40 ℃; for 4h;

DOI:10.1021/jm060133g

Reference yield:

N-(isobutyl-[1,3,4]thiadiazol-2-yl)-isovaleramide (331819-06-8) → 2-amino-5-isobutyl-1,3,4-thiadiazole (52057-89-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/ardp.19512840202

Reference yield:

3-methylbutyric acid (503-74-2) + thiosemicarbazide (79-19-6) → 2-amino-5-isobutyl-1,3,4-thiadiazole (52057-89-3)

Guidance literature:

With sulfuric acid;

DOI:10.1139/v59-165

upstream raw materials:

N-(isobutyl-[1,3,4]thiadiazol-2-yl)-isovaleramide

3-methylbutyric acid

thiosemicarbazide

isopentanoyl chloride

Downstream raw materials:

4-chloro-benzenesulfonic acid-(5-isobutyl-[1,3,4]thiadiazol-2-ylamide)

4-acetylamino-N-(5-isobutyl-[1,3,4]thiadiazol-2-yl)-benzenesulfonamide

phenylpropynoic acid 5-isobutyl-[1,3,4]thiadiazol-2-ylamide

6,8-dibromo-3-(5-isobutyl-[1,3,4]thiadiazol-2-yl)-2-phenyl-3H-quinazolin-4-one