1-(4-Chlorophenyl)-2-methyl-2-morpholinopropan-1-one

Base Information

• Chemical Name: 1-(4-Chlorophenyl)-2-methyl-2-morpholinopropan-1-one
• CAS No.: 88324-57-6
• Molecular Formula: C14H18ClNO2
• Molecular Weight: 267.755
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID60577061
• Nikkaji Number: J3.363.121I
• Wikidata: Q82466981
• Mol file: 88324-57-6.mol

Synonyms:1-(4-Chlorophenyl)-2-methyl-2-morpholinopropan-1-one;88324-57-6;1-(4-chlorophenyl)-2-methyl-2-morpholin-4-ylpropan-1-one;1-(4-Chlorophenyl)-2-methyl-2-(morpholin-4-yl)propan-1-one;SCHEMBL2703478;DTXSID60577061;IIWLVHAOFQNHDW-UHFFFAOYSA-N;AKOS015998864;A862240;1-(4-chlorophenyl)-2-methyl-2-morpholino-propan-1-one;1-(4-chlorophenyl)-2-methyl-2-morpholin-4-yl-propan-1-one

Chemical Property of 1-(4-Chlorophenyl)-2-methyl-2-morpholinopropan-1-one

Chemical Property:

• PSA: 29.54000
• LogP: 2.57140
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 267.1026065
• Heavy Atom Count: 18
• Complexity: 292

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Chlorophenyl)-2-methyl-2-morpholinopropan-1-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(=O)C1=CC=C(C=C1)Cl)N2CCOCC2

Technology Process of 1-(4-Chlorophenyl)-2-methyl-2-morpholinopropan-1-one

There total 3 articles about 1-(4-Chlorophenyl)-2-methyl-2-morpholinopropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C14H20ClNO2 (1309453-90-4) → 1-(4-chlorophenyl)-2-methyl-2-morpholin-4-yl-propan-1-one (88324-57-6)

Guidance literature:

With oxygen; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.tet.2011.03.052

Reference yield:

morpholine (110-91-8,99108-56-2) + 2-(4-chloro-phenyl)-2-methoxy-3,3-dimethyl-oxirane (33000-65-6) → 1-(4-chlorophenyl)-2-methyl-2-morpholin-4-yl-propan-1-one (88324-57-6)

Guidance literature:

at 130 ℃; for 22h; Inert atmosphere;

Reference yield:

→ 1-(4-chlorophenyl)-2-methyl-2-morpholin-4-yl-propan-1-one (88324-57-6)

Guidance literature:

upstream raw materials:

C₁₄H₂₀ClNO₂

morpholine

2-(4-chloro-phenyl)-2-methoxy-3,3-dimethyl-oxirane

Downstream raw materials:

C₄₂H₆₁N₃O₁₁

C₃₅H₅₁NO₁₁S

2-methyl-2-morpholin-4-yl-1-(4-piperazinylphenyl)propan-1-one

1-[4-(10-mercaptodecanylthio)-phenyl]-2-methyl-2-morpholine-4-yl-propane-1-one