4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-[(cyclohex yloxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-

Base Information

Chemical Name:4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-[(cyclohex yloxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-
CAS No.:883441-77-8
Molecular Formula:C25H38F2N2O5
Molecular Weight:484.584
Hs Code.:

4-Morpholinecarboxylic acid,
5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-[(cyclohex
yloxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-[(cyclohex yloxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-

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Technology Process of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-[(cyclohex yloxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)-

There total 1 articles about 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-[(cyclohex yloxy)methyl]-, 1,1-dimethylethyl ester, (2R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.1%

: 883441-76-7
(2R,5R)-5-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-cyclohexyloxymethyl-morpholine-4-carboxylic acid tert-butyl ester

: 883441-77-8
(2R,5R)-5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-cyclohexyloxymethylmorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium(II) hydroxide/carbon; In ethanol; for 60h; under 760.051 Torr;

Reference yield: 80.1%

: 883441-77-8
(2R,5R)-5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-cyclohexyloxymethylmorpholine-4-carboxylic acid tert-butyl ester

: 108-24-7
acetic anhydride

: 883441-72-3
(2R,5R)-5-[(1S,2S)-2-acetylamino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-cyclohexyloxymethylmorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 1.5h;

Reference yield: 45.2%

: 883441-77-8
(2R,5R)-5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-cyclohexyloxymethylmorpholine-4-carboxylic acid tert-butyl ester

: 883441-78-9
(2R,5R)-2-Cyclohexyloxymethyl-5-[(1S,2S)-3-(3,5-difluorophenyl)-2-((E)-3-dipropylcarbamoyl-2-methylacryloylamino)-1-hydroxypropyl]-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: (E)-3-dipropylcarbamoyl-2-methylacrylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

(2R,5R)-5-[(1S,2S)-2-amino-3-(3,5-difluorophenyl)-1-hydroxypropyl]-2-cyclohexyloxymethylmorpholine-4-carboxylic acid tert-butyl ester; In dichloromethane; for 2.5h;

With potassium carbonate; In dichloromethane; water;