4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-hydroxy-, 1,1-dimethylethyl ester, (5R)-

Base Information

Chemical Name:4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-hydroxy-, 1,1-dimethylethyl ester, (5R)-
CAS No.:883442-72-6
Molecular Formula:C39H44F2N2O5
Molecular Weight:658.786
Hs Code.:

4-Morpholinecarboxylic acid,
5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl
methoxy)propyl]-2-hydroxy-, 1,1-dimethylethyl ester, (5R)-

Synonyms:

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Chemical Property of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-hydroxy-, 1,1-dimethylethyl ester, (5R)-

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Technology Process of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-hydroxy-, 1,1-dimethylethyl ester, (5R)-

There total 3 articles about 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-hydroxy-, 1,1-dimethylethyl ester, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 883442-71-5
tert-butyl (5R)-5-[(1S,2S)-1-benzyloxy-3-(3,5-difluorophenyl)-2-methylpropyl]-2-oxomorpholine-4-carboxylate

: 883442-72-6
(3S,5R)-5-{(1S,2S)-2-Dibenzylamino-3-[3,5-difluorophenyl]-1-benzyloxy-propyl}-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl (5R)-5-[(1S,2S)-1-benzyloxy-3-(3,5-difluorophenyl)-2-methylpropyl]-2-oxomorpholine-4-carboxylate; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h;

With Rochelle's salt; In methanol; water; ethyl acetate;

Reference yield:

: C₃₂H₃₄F₂N₂O₂*2ClH

: 883442-72-6
(3S,5R)-5-{(1S,2S)-2-Dibenzylamino-3-[3,5-difluorophenyl]-1-benzyloxy-propyl}-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

1.2: 6 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

3.1: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.7b01304

Reference yield:

: C₃₄H₃₄F₂N₂O₃

: 883442-72-6
(3S,5R)-5-{(1S,2S)-2-Dibenzylamino-3-[3,5-difluorophenyl]-1-benzyloxy-propyl}-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

2: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/acs.jmedchem.7b01304