4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-(2-fluoro-2-methylpropoxy)-, 1,1-dimethylethyl ester, (2S,5R)-

Base Information

Chemical Name:4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-(2-fluoro-2-methylpropoxy)-, 1,1-dimethylethyl ester, (2S,5R)-
CAS No.:883443-08-1
Molecular Formula:C43H51F3N2O5
Molecular Weight:732.884
Hs Code.:

4-Morpholinecarboxylic acid,
5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl
methoxy)propyl]-2-(2-fluoro-2-methylpropoxy)-, 1,1-dimethylethyl ester,
(2S,5R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-(2-fluoro-2-methylpropoxy)-, 1,1-dimethylethyl ester, (2S,5R)-

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Technology Process of 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-(2-fluoro-2-methylpropoxy)-, 1,1-dimethylethyl ester, (2S,5R)-

There total 1 articles about 4-Morpholinecarboxylic acid, 5-[(1S,2S)-2-[bis(phenylmethyl)amino]-3-(3,5-difluorophenyl)-1-(phenyl methoxy)propyl]-2-(2-fluoro-2-methylpropoxy)-, 1,1-dimethylethyl ester, (2S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 145349-17-3
(2-fluoro-2-methylpropyl) trifluoromethanesulfonate

: 883443-08-1
(2S,5R)-5-[(1S,2S)-1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenylpropyl)-2-(2-fluoro-2-methylpropoxy)]-morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:: (3S,5R)-5-{(1S,2S)-2-Dibenzylamino-3-[3,5-difluorophenyl]-1-benzyloxy-propyl}-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

(2-fluoro-2-methylpropyl) trifluoromethanesulfonate; In N,N-dimethyl-formamide; for 1h;

With water; In N,N-dimethyl-formamide;