4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one

Base Information

• Chemical Name: 4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one
• CAS No.: 88353-24-6
• Molecular Formula: C16H12N2O4
• Molecular Weight: 296.27700
• DSSTox Substance ID: DTXSID70362869
• Wikidata: Q82146354
• ChEMBL ID: CHEMBL1331741
• Mol file: 88353-24-6.mol

Synonyms:STK561704;88353-24-6;BAS 01052273;Oprea1_559501;MLS000710242;3-nitro-4-p-tolylaminocoumarin;4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one;CHEMBL1331741;DTXSID70362869;HMS2672C13;STK999313;AKOS000636146;AKOS005487065;SMR000279064;SR-01000310460;SR-01000310460-1;BRD-K50865252-001-04-7;(4E)-4-[(4-methylphenyl)imino]-3-nitro-4H-chromen-2-ol

Chemical Property of 4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one

Chemical Property:

• PSA: 88.06000
• LogP: 4.34940
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 296.07970687
• Heavy Atom Count: 22
• Complexity: 489

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC2=C(C(=O)OC3=CC=CC=C32)[N+](=O)[O-]

Technology Process of 4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one

There total 2 articles about 4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-toluidine (106-49-0,12221-03-3) + 4-chloro-3-nitro-chromen-2-one (38464-20-9) → 4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one (88353-24-6)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 18 - 20 ℃; for 2h;

DOI:10.1007/BF00474483

Reference yield:

3-nitro-4-(benzylthio)coumarin (88369-11-3) + p-toluidine (106-49-0,12221-03-3) → 4-[(4-methylphenyl)amino]-3-nitro-2H-chromen-2-one (88353-24-6)

Guidance literature:

With sulfuryl dichloride; triethylamine; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1.) CHCl₃, 18-20 deg C, 2 h, 2.) CHCl₃, 18-20 deg C, 1 h;

DOI:10.1007/BF00474483

upstream raw materials:

3-nitro-4-(benzylthio)coumarin

p-toluidine

4-chloro-3-nitro-chromen-2-one