Morpholine, 2-(1-(2-methoxyphenoxy)-1-phenylethyl)-, hydrochloride

Base Information

Chemical Name:Morpholine, 2-(1-(2-methoxyphenoxy)-1-phenylethyl)-, hydrochloride
CAS No.:93851-95-7
Molecular Formula:C₁₉H₂₃NO₃*ClH
Molecular Weight:349.857
Hs Code.:
DSSTox Substance ID:DTXSID30917490

Synonyms:Morpholine, 2-(1-(2-methoxyphenoxy)-1-phenylethyl)-, hydrochloride;2-(alpha-(o-Methoxyphenoxy)-alpha-methylbenzyl)morpholine hydrochloride;Morpholine, 2-(alpha-(o-methoxyphenoxy)-alpha-methylbenzyl)-, hydrochloride;93851-95-7;DTXSID30917490;LS-93108;2-[1-(2-Methoxyphenoxy)-1-phenylethyl]morpholine--hydrogen chloride (1/1)

Suppliers and Price of Morpholine, 2-(1-(2-methoxyphenoxy)-1-phenylethyl)-, hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Morpholine, 2-(1-(2-methoxyphenoxy)-1-phenylethyl)-, hydrochloride

Chemical Property:

Vapor Pressure:5.23E-08mmHg at 25°C
Boiling Point:441.9°Cat760mmHg
Flash Point:187.7°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:349.1444713
Heavy Atom Count:24
Complexity:359

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1CNCCO1)(C2=CC=CC=C2)OC3=CC=CC=C3OC.Cl

Technology Process of Morpholine, 2-(1-(2-methoxyphenoxy)-1-phenylethyl)-, hydrochloride

There total 11 articles about Morpholine, 2-(1-(2-methoxyphenoxy)-1-phenylethyl)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93886-40-9
6-[1-(2-Methoxy-phenoxy)-1-phenyl-ethyl]-morpholin-3-one

: 93851-95-7
2-[1-(2-Methoxy-phenoxy)-1-phenyl-ethyl]-morpholine; hydrochloride

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 20h; Yield given; Ambient temperature;

Reference yield:

: 10606-73-2,99531-04-1,116836-53-4,4773-33-5
ethyl 2-chloro-2-phenylacetate

: 93851-95-7
2-[1-(2-Methoxy-phenoxy)-1-phenyl-ethyl]-morpholine; hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: 83 percent / NaH / dimethylformamide / 1.) 1 h, RT; 2.) 45 min, 40 deg C

3: KOH / methanol / 20 h / Ambient temperature

4: SOCl₂ / 16 h / Ambient temperature

5: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

6: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

7: BH₃ / tetrahydrofuran / 20 h / Ambient temperature

8: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

9: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

10: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; potassium hydroxide; thionyl chloride; borane; potassium tert-butylate; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; dichloromethane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 93852-28-9
ethyl α-(2-methoxy-phenoxy)-α-phenylpropionate

: 93851-95-7
2-[1-(2-Methoxy-phenoxy)-1-phenyl-ethyl]-morpholine; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: KOH / methanol / 20 h / Ambient temperature

2: SOCl₂ / 16 h / Ambient temperature

3: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

4: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

5: BH₃ / tetrahydrofuran / 20 h / Ambient temperature

6: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

7: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

8: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

With potassium cyanide; sodium metabisulfite; potassium hydroxide; thionyl chloride; borane; potassium tert-butylate; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; dichloromethane; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;