4-CHLORO-5,7-DIMETHOXYQUINAZOLINE

Base Information

• Chemical Name: 4-CHLORO-5,7-DIMETHOXYQUINAZOLINE
• CAS No.: 884340-91-4
• Molecular Formula: C10H9ClN2O2
• Molecular Weight: 224.647
• Hs Code.: 2933990090
• Mol file: 884340-91-4.mol

Synonyms:4-chloro-5,7-bis(methyloxy)quinazoline;4-chloro-5,7-dimethoxy-quinazoline;

Chemical Property of 4-CHLORO-5,7-DIMETHOXYQUINAZOLINE

Chemical Property:

• PSA: 44.24000
• LogP: 2.30040
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-5,7-dimethoxyquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-5,7-DIMETHOXYQUINAZOLINE

There total 5 articles about 4-CHLORO-5,7-DIMETHOXYQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

5,7-dimethoxyquinazolin-4(3H)-one (379228-27-0) → 4-chloro-5,7-bis(methyloxy)quinazoline (884340-91-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetonitrile; for 2h; Heating / reflux;

Reference yield:

2-amino-4,6-dimethoxybenzoic acid (21577-57-1) → 4-chloro-5,7-bis(methyloxy)quinazoline (884340-91-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / ethanol; CH₂Cl₂ / 0 °C

2: 94 percent / 2-methoxy-ethanol / 2 h / Heating

3: POCl₃; DIPEA / 1,2-dichloro-ethane / 2 h / Heating

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dichloromethane; 2-methoxy-ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm060434q

Reference yield:

5,7-dimethoxyquinazolin-4-ol → 4-chloro-5,7-bis(methyloxy)quinazoline (884340-91-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,2-dichloro-ethane; at 80 ℃; for 4h;

upstream raw materials:

5,7-dimethoxyquinazolin-4(3H)-one

2-amino-4,6-dimethoxybenzoic acid

methyl 2-amino-4,6-dimethoxybenzoate

Downstream raw materials:

(2-chloro-5-methoxy-phenyl)-(5,7-dimethoxy-quinazolin-4-yl)-amine

3-{[5,7-bis(methyloxy)-4-quinazolinyl]amino}-4-(dimethylamino)-N-methylbenzenesulfonamide

C₂₂H₂₁N₅O₅

4-[(2-chloro-5-methoxyphenyl)amino]-7-methoxyquinazolin-5-ol

Refernces

• 1、 -. "PYRAZOLYLAMINO SUBSTITUTED QUINAZOLES FOR THE TREATMENT OF CANCER". Page/Page column 49-50. . Retrieved 2008/06/13.
• 2、 -. "QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER". Page/Page column 84. . Retrieved 2008/06/13.