4-Piperidineacetic acid, 1-[(1R)-4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl]-2-[4-(trifluoromethyl) phenyl]-, methyl ester, (2S,4R)-

Base Information

• Chemical Name: 4-Piperidineacetic acid, 1-[(1R)-4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl]-2-[4-(trifluoromethyl) phenyl]-, methyl ester, (2S,4R)-
• CAS No.: 884602-80-6
• Molecular Formula: C28H33F6NO2
• Molecular Weight: 529.566
• Mol file: 884602-80-6.mol

Synonyms:

Chemical Property of 4-Piperidineacetic acid, 1-[(1R)-4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl]-2-[4-(trifluoromethyl) phenyl]-, methyl ester, (2S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Piperidineacetic acid, 1-[(1R)-4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl]-2-[4-(trifluoromethyl) phenyl]-, methyl ester, (2S,4R)-

There total 2 articles about 4-Piperidineacetic acid, 1-[(1R)-4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl]-2-[4-(trifluoromethyl) phenyl]-, methyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(+/-)-methyl {(2S*,4R*)-1-{4-methyl-1-[4-(trifluoromethyl)phenyl]pent-4-en-2-yn-1-yl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate → (+/-)-methyl-{(2S*,4R*)-1-(1R*)-{4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (884602-80-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 16h;

Reference yield:

C28H29F6NO2 (1404070-33-2) → (+/-)-methyl-{(2S*,4R*)-1-(1R*)-{4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (884602-80-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; under 50 Torr;

DOI:10.1016/j.bmcl.2009.11.034

Reference yield:

(+/-)-methyl-{(2S*,4R*)-1-(1R*)-{4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate (884602-80-6) → C28H31F8NO3 (1207683-28-0)

Guidance literature:

(+/-)-methyl-{(2S*,4R*)-1-(1R*)-{4-methyl-1-[4-(trifluoromethyl)phenyl]pentyl}-2-[4-(trifluoromethyl)phenyl]piperidin-4-yl}acetate; With Selectfluor; In N,N-dimethyl-formamide;

With water; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2009.11.034

upstream raw materials:

C₂₈H₂₉F₆NO₂

Downstream raw materials:

C₂₈H₃₁F₈NO₃