ethyl 1,2-dimethyl-5-{[(4-methylphenyl)sulfonyl]oxy}-1H-indole-3-carboxylate

Base Information

Chemical Name:ethyl 1,2-dimethyl-5-{[(4-methylphenyl)sulfonyl]oxy}-1H-indole-3-carboxylate
CAS No.:88461-72-7
Molecular Formula:C20H21NO5S
Molecular Weight:387.44900
Hs Code.:
Mol file:88461-72-7.mol

Synonyms:1,2-Dimethyl-5-(toluene-4-sulfonyloxy)-1H-indole-3-carboxylic acid ethyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 1,2-dimethyl-5-{[(4-methylphenyl)sulfonyl]oxy}-1H-indole-3-carboxylate

Chemical Property:

PSA：82.98000
LogP:4.82030

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 1,2-dimethyl-5-{[(4-methylphenyl)sulfonyl]oxy}-1H-indole-3-carboxylate

There total 1 articles about ethyl 1,2-dimethyl-5-{[(4-methylphenyl)sulfonyl]oxy}-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.5%

: 15574-49-9
mecarbinate

: 98-59-9
p-toluenesulfonyl chloride

: 88461-72-7
1,2-Dimethyl-3-ethoxycarbonyl-5-tosyloxyindole

Guidance literature:: With potassium carbonate; In acetone; for 5h; Heating;
DOI:10.1007/BF00764691

Reference yield: 61.0%

: 88461-72-7
1,2-Dimethyl-3-ethoxycarbonyl-5-tosyloxyindole

: 88461-74-9
1-Methyl-2-bromomethyl-3-ethoxycarbonyl-5-tosyloxyindole

Guidance literature:: With bromine; In tetrachloromethane; 1.) reflux, 4 h, irradiation, 2.) reflux, 2 h; room temp., overnight;
DOI:10.1007/BF00764691

Reference yield:

: 88461-72-7
1,2-Dimethyl-3-ethoxycarbonyl-5-tosyloxyindole

: 109114-61-6
1-Methyl-2-diethylaminomethyl-3-ethoxycarbonyl-5-tosyloxyindole

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / 1.) Br₂ / CCl₄ / 1.) reflux, 4 h, irradiation, 2.) reflux, 2 h; room temp., overnight

2: 94.7 percent / benzene / 22 h / Ambient temperature

With bromine; In tetrachloromethane; benzene;
DOI:10.1007/BF00764691