Donepezil hydrochloride monohydrate

Base Information

Chemical Name:Donepezil hydrochloride monohydrate
CAS No.:884740-09-4
Molecular Formula:C24H29NO3.ClH.H2O
Molecular Weight:433.975
Hs Code.:
European Community (EC) Number:804-791-0
UNII:7KZL5YRL6W
ChEMBL ID:CHEMBL2337271
DSSTox Substance ID:DTXSID50470774
Wikidata:Q27268490

Synonyms:Donepezil hydrochloride monohydrate;884740-09-4;2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrochloride hydrate;7KZL5YRL6W;2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrate;hydrochloride;CHEMBL2337271;1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, hydrochloride, hydrate (1:1:1);1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, hydrochloride, monohydrate;UNII-7KZL5YRL6W;SCHEMBL1123745;DTXSID50470774;HLJIZAKUNCTCQX-UHFFFAOYSA-N;DONEPEZIL HYDROCHLORIDE MONOHYDRATE [WHO-DD];Q27268490;DONEPEZIL HYDROCHLORIDE MONOHYDRATE [EP MONOGRAPH];2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-onehydrochloridehydrate

Suppliers and Price of Donepezil hydrochloride monohydrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Donepezil hydrochloride monohydrate

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:433.2019862
Heavy Atom Count:30
Complexity:510

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.O.Cl

Technology Process of Donepezil hydrochloride monohydrate

There total 2 articles about Donepezil hydrochloride monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142057-77-0
donepezil hydrochloride

: 884740-09-4
1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride monohydrate

Guidance literature:: donepezil hydrochloride; With water; In methanol; at 0 - 5 ℃; for 0.166667h;

In methanol; tert-butyl methyl ether; at 0 - 5 ℃; for 0.583333h;

Reference yield:

: 120014-06-4,142057-79-2,142057-80-5,142698-19-9
donepezil

: 884740-09-4
1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride monohydrate

Guidance literature:: With hydrogenchloride; water; In methanol; ethyl acetate; at -10 - 20 ℃; for 0.783333h; Product distribution / selectivity;