10-propargyl-5-deazaaminopterin analog of folic acid

Base Information

• Chemical Name: 10-propargyl-5-deazaaminopterin analog of folic acid
• CAS No.: 135423-84-6
• Molecular Formula: C23H23 N7 O5
• Molecular Weight: 477.47
• Mol file: 135423-84-6.mol

Synonyms:L-Glutamicacid, N-[4-[[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]-2-propynylamino]benzoyl]-(9CI); Pyrido[2,3-d]pyrimidine, L-glutamic acid deriv.

Chemical Property of 10-propargyl-5-deazaaminopterin analog of folic acid

Chemical Property:

• PSA: 197.65000
• Density: 1.495g/cm³
• LogP: 2.43010

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 10-propargyl-5-deazaaminopterin analog of folic acid

There total 1 articles about 10-propargyl-5-deazaaminopterin analog of folic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

10-propargyl-5-deazaaminopterin diethyl ester (135423-82-4) → 10-propargyl-5-deazaaminopterin (135423-84-6)

Guidance literature:

With sodium hydroxide; In methanol; at 20 - 25 ℃; for 24h;

DOI:10.1021/jm00080a019

upstream raw materials:

10-propargyl-5-deazaaminopterin diethyl ester

Refernces