4-(Ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl 3,4-dimethoxybenzoate HCl

Base Information

Chemical Name:4-(Ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl 3,4-dimethoxybenzoate HCl
CAS No.:69788-31-4
Molecular Formula:C₂₆H₃₅NO₅*ClH
Molecular Weight:478.029
Hs Code.:
DSSTox Substance ID:DTXSID00990033
ChEMBL ID:CHEMBL543275

Synonyms:4-(Ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl 3,4-dimethoxybenzoate HCl;69788-31-4;Benzoic acid, 3,4-dimethoxy-, 4-(ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl ester, hydrochloride;C26H35NO5.ClH;CHEMBL543275;SCHEMBL11491499;DTXSID00990033;C26-H35-N-O5.Cl-H;LS-37129;4-[Ethyl(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)amino]butyl 3,4-dimethoxybenzoate--hydrogen chloride (1/1)

Suppliers and Price of 4-(Ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl 3,4-dimethoxybenzoate HCl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 4-(Ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl 3,4-dimethoxybenzoate HCl

Chemical Property:

Vapor Pressure:1.38E-13mmHg at 25°C
Boiling Point:583.1°Cat760mmHg
Flash Point:306.5°C
Density:g/cm³
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:477.2282009
Heavy Atom Count:33
Complexity:558

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CCCCOC(=O)C1=CC(=C(C=C1)OC)OC)C2CCC3=C(C2)C=CC(=C3)OC.Cl

Technology Process of 4-(Ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl 3,4-dimethoxybenzoate HCl

There total 7 articles about 4-(Ethyl(1,2,3,4-tetrahydro-6-methoxy-2-naphthalenyl)amino)butyl 3,4-dimethoxybenzoate HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.8%

: 69788-95-0
N-ethyl-N-(4-hydroxybutyl)-6-methoxy-1,2,3,4-tetrahydro-2-naphthylamine

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 69788-31-4
N-ethyl-N-<4-<(3,4-dimethoxybenzoyl)oxy>butyl>-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine hydrochloride

Guidance literature:: With triethylamine; In benzene; for 3h; Heating;
DOI:10.1248/cpb.30.180

Reference yield:

: 2471-71-8
(2RS)-N-(6-methoxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide

: 69788-31-4
N-ethyl-N-<4-<(3,4-dimethoxybenzoyl)oxy>butyl>-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 95.7 percent / H₂, HClO₄ / 15percent Pd-C / acetic acid

2: 97.6 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

3: 91.3 percent / triethylamine / benzene / 1.) 1 h, room temp., 2.) 2 h, reflux

4: 85.8 percent / LiAlH₄ / tetrahydrofuran / 1.) 0.5 h, room temp., 2.) 4 h, reflux

5: 41.8 percent / triethylamine / benzene / 3 h / Heating

With lithium aluminium tetrahydride; perchloric acid; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetic acid; benzene;
DOI:10.1248/cpb.30.180

Reference yield:

: 69788-93-8
N-ethyl-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine

: 69788-31-4
N-ethyl-N-<4-<(3,4-dimethoxybenzoyl)oxy>butyl>-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 91.3 percent / triethylamine / benzene / 1.) 1 h, room temp., 2.) 2 h, reflux

2: 85.8 percent / LiAlH₄ / tetrahydrofuran / 1.) 0.5 h, room temp., 2.) 4 h, reflux

3: 41.8 percent / triethylamine / benzene / 3 h / Heating

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; benzene;
DOI:10.1248/cpb.30.180