1,3,4-Thiadiazole, 2-(3-azidopropyl)-5-(2,5-difluorophenyl)-3-[(2S)-2-[[(1,1-dimethylethyl)di phenylsilyl]oxy]-1-oxopropyl]-2,3-dihydro-2-phenyl-, (2R)-

Base Information

Chemical Name:1,3,4-Thiadiazole, 2-(3-azidopropyl)-5-(2,5-difluorophenyl)-3-[(2S)-2-[[(1,1-dimethylethyl)di phenylsilyl]oxy]-1-oxopropyl]-2,3-dihydro-2-phenyl-, (2R)-
CAS No.:885060-39-9
Molecular Formula:C36H37F2N5O2SSi
Molecular Weight:669.87
Hs Code.:

1,3,4-Thiadiazole,
2-(3-azidopropyl)-5-(2,5-difluorophenyl)-3-[(2S)-2-[[(1,1-dimethylethyl)di
phenylsilyl]oxy]-1-oxopropyl]-2,3-dihydro-2-phenyl-, (2R)-

Synonyms:

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Chemical Property of 1,3,4-Thiadiazole, 2-(3-azidopropyl)-5-(2,5-difluorophenyl)-3-[(2S)-2-[[(1,1-dimethylethyl)di phenylsilyl]oxy]-1-oxopropyl]-2,3-dihydro-2-phenyl-, (2R)-

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Technology Process of 1,3,4-Thiadiazole, 2-(3-azidopropyl)-5-(2,5-difluorophenyl)-3-[(2S)-2-[[(1,1-dimethylethyl)di phenylsilyl]oxy]-1-oxopropyl]-2,3-dihydro-2-phenyl-, (2R)-

There total 7 articles about 1,3,4-Thiadiazole, 2-(3-azidopropyl)-5-(2,5-difluorophenyl)-3-[(2S)-2-[[(1,1-dimethylethyl)di phenylsilyl]oxy]-1-oxopropyl]-2,3-dihydro-2-phenyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885060-37-7
2-(3-azido-propyl)-5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole

: 125941-75-5
(S)-2-[(1,1-dimethylethyl)diphenylsilyl]oxypropanoic acid

: 885060-38-8
(S)-1-[(S)-2-(3-azido-propyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-(tert-butyl-diphenyl-silanyloxy)-propan-1-one

: 885060-39-9
(S)-1-[(R)-2-(3-azido-propyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-(tert-butyl-diphenyl-silanyloxy)-propan-1-one

Guidance literature:: (S)-2-[(1,1-dimethylethyl)diphenylsilyl]oxypropanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 ℃; for 0.25h;

2-(3-azido-propyl)-5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole; In acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 885060-36-6
2,5-difluoro-benzothiohydrazide

: 885060-38-8
(S)-1-[(S)-2-(3-azido-propyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-(tert-butyl-diphenyl-silanyloxy)-propan-1-one

: 885060-39-9
(S)-1-[(R)-2-(3-azido-propyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-(tert-butyl-diphenyl-silanyloxy)-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; dichloromethane / 16 h / 20 °C

1.2: 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 0.25 h / 20 °C

2.2: 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1021853-64-4
C₇H₄F₂S₂

: 885060-38-8
(S)-1-[(S)-2-(3-azido-propyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-(tert-butyl-diphenyl-silanyloxy)-propan-1-one

: 885060-39-9
(S)-1-[(R)-2-(3-azido-propyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-(tert-butyl-diphenyl-silanyloxy)-propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water / 14 h / 20 °C

2.1: sodium hydroxide; hydrazine / 14 h / 0 - 20 °C

3.1: ethanol; dichloromethane / 16 h / 20 °C

3.2: 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 0.25 h / 20 °C

4.2: 16 h / 20 °C

With sodium hydroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; hydrazine; In ethanol; dichloromethane; water; acetonitrile;