2-Benzofurancarboxylic acid, 2,3-dihydro-5-[2-methoxy-6-[[2-[4-(trifluoromethoxy)phenyl]ethyl]amino]- 4-pyrimidinyl]-, monohydrochloride

Base Information

Chemical Name:2-Benzofurancarboxylic acid, 2,3-dihydro-5-[2-methoxy-6-[[2-[4-(trifluoromethoxy)phenyl]ethyl]amino]- 4-pyrimidinyl]-, monohydrochloride
CAS No.:885069-02-3
Molecular Formula:C23H20F3N3O5.ClH
Molecular Weight:511.885
Hs Code.:

2-Benzofurancarboxylic acid,
2,3-dihydro-5-[2-methoxy-6-[[2-[4-(trifluoromethoxy)phenyl]ethyl]amino]-
4-pyrimidinyl]-, monohydrochloride

Synonyms:

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Chemical Property of 2-Benzofurancarboxylic acid, 2,3-dihydro-5-[2-methoxy-6-[[2-[4-(trifluoromethoxy)phenyl]ethyl]amino]- 4-pyrimidinyl]-, monohydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 2-Benzofurancarboxylic acid, 2,3-dihydro-5-[2-methoxy-6-[[2-[4-(trifluoromethoxy)phenyl]ethyl]amino]- 4-pyrimidinyl]-, monohydrochloride

There total 4 articles about 2-Benzofurancarboxylic acid, 2,3-dihydro-5-[2-methoxy-6-[[2-[4-(trifluoromethoxy)phenyl]ethyl]amino]- 4-pyrimidinyl]-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885069-69-2
5-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-benzofuran-2-carboxylic acid

: 885069-02-3
5-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-benzofuran-2-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;

Reference yield:

: 885069-04-5
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-benzofuran-2-carboxylic acid

: 885069-02-3
5-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-benzofuran-2-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 23.08 h / 60 °C

2: hydrogenchloride / diethyl ether

With hydrogenchloride; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; diethyl ether; water;

Reference yield:

: 885069-03-4
5-bromo-2,3-dihydro-1-benzofuran-2-carboxylic acid

: 885069-02-3
5-{2-methoxy-6-[2-(4-trifluoromethoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-2,3-dihydro-benzofuran-2-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 16.08 h / 90 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 23.08 h / 60 °C

3: hydrogenchloride / diethyl ether

With hydrogenchloride; potassium acetate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; diethyl ether; water; dimethyl sulfoxide;