4-[Bis(4-fluorophenyl)methoxy]piperidine

Base Information

Chemical Name:4-[Bis(4-fluorophenyl)methoxy]piperidine
CAS No.:88535-96-0
Molecular Formula:C18H19F2NO
Molecular Weight:303.352
Hs Code.:
ChEMBL ID:CHEMBL3260912
DSSTox Substance ID:DTXSID50518281
Nikkaji Number:J1.857.690B
Wikidata:Q82380870

Synonyms:4-[bis(4-fluorophenyl)methoxy]piperidine;88535-96-0;SCHEMBL6982214;CHEMBL3260912;DTXSID50518281

Suppliers and Price of 4-[Bis(4-fluorophenyl)methoxy]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-[Bis(4-fluorophenyl)methoxy]piperidine

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:303.14347055
Heavy Atom Count:22
Complexity:297

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1OC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F

Technology Process of 4-[Bis(4-fluorophenyl)methoxy]piperidine

There total 2 articles about 4-[Bis(4-fluorophenyl)methoxy]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 365-24-2
4,4'-difluorobenzhydryl alcohol

: 88535-96-0
4-piperidine

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 2h; Heating;
DOI:10.1248/cpb.51.122

Reference yield:

: 345-92-6
4,4'-Difluorobenzophenone

: 88535-96-0
4-piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: 29.2 g / sodium borohydride / ethanol; tetrahydrofuran / 0.5 h / 20 °C

2: p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating

With sodium tetrahydroborate; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; toluene;
DOI:10.1248/cpb.51.122