L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-isothiocyanato-, methyl ester

Base Information

Chemical Name:L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-isothiocyanato-, methyl ester
CAS No.:88576-96-9
Molecular Formula:C26H22N2O4S
Molecular Weight:458.52900
Hs Code.:

Synonyms:(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-isothiocyanato-phenyl)-propionic acid methyl ester;

Suppliers and Price of L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-isothiocyanato-, methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-isothiocyanato-, methyl ester

Chemical Property:

Boiling Point:668.0±55.0 °C(Predicted)
PSA：109.08000
Density:1.26±0.1 g/cm3(Predicted)
LogP:5.43460

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-isothiocyanato-, methyl ester

There total 3 articles about L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-isothiocyanato-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 463-71-8
thiophosgene

: 95753-57-4
N-Fmoc-L-p-aminophenylalanine methyl ester hydrochloride

: 88576-96-9
Fmoc-L-p-isothiocyanophenylalanine methyl ester

Guidance literature:: With sodium hydrogencarbonate; In chloroform; water; for 2h; Ambient temperature;
DOI:10.1039/P29840001723

Reference yield:

: 95753-55-2,177966-63-1
N-α-FMOC-4-nitro-L-phenylalanine

: 88576-96-9
Fmoc-L-p-isothiocyanophenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / H₂ / 10percent Pd-C / dioxane / 1 h / Ambient temperature

2: SOCl₂

3: 79 percent / 1 M NaHCO₃ / CHCl₃; H₂O / 2 h / Ambient temperature

With thionyl chloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In 1,4-dioxane; chloroform; water;
DOI:10.1039/P29840001723

Reference yield:

: 95753-56-3,324017-21-2
4-amino-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine

: 88576-96-9
Fmoc-L-p-isothiocyanophenylalanine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂

2: 79 percent / 1 M NaHCO₃ / CHCl₃; H₂O / 2 h / Ambient temperature

With thionyl chloride; sodium hydrogencarbonate; In chloroform; water;
DOI:10.1039/P29840001723