N-[(Z)-Amino(phenyl)methylidene]-5-ethoxy-2-phenyl-1,3-oxazole-4-carboxamide

Base Information

Chemical Name:N-[(Z)-Amino(phenyl)methylidene]-5-ethoxy-2-phenyl-1,3-oxazole-4-carboxamide
CAS No.:88584-27-4
Molecular Formula:C19H17N3O3
Molecular Weight:335.362
Hs Code.:
DSSTox Substance ID:DTXSID80518557

Synonyms:88584-27-4;DTXSID80518557;N-[(Z)-Amino(phenyl)methylidene]-5-ethoxy-2-phenyl-1,3-oxazole-4-carboxamide

Suppliers and Price of N-[(Z)-Amino(phenyl)methylidene]-5-ethoxy-2-phenyl-1,3-oxazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-[(Z)-Amino(phenyl)methylidene]-5-ethoxy-2-phenyl-1,3-oxazole-4-carboxamide

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:335.12699141
Heavy Atom Count:25
Complexity:471

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=C(N=C(O1)C2=CC=CC=C2)C(=O)N=C(C3=CC=CC=C3)N

Technology Process of N-[(Z)-Amino(phenyl)methylidene]-5-ethoxy-2-phenyl-1,3-oxazole-4-carboxamide

There total 2 articles about N-[(Z)-Amino(phenyl)methylidene]-5-ethoxy-2-phenyl-1,3-oxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 54644-14-3
2-phenyl-5-ethoxyoxazole-4-carboxylic acid chloride

: 1670-14-0
benzamidine monohydrochloride

: 88584-27-4
5-Ethoxy-2-phenyl-oxazole-4-carboxylic acid 1-amino-1-phenyl-meth-(E)-ylideneamide

Guidance literature:: With sodium hydroxide; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1055/s-1983-30535

Reference yield:

: 54644-12-1
5-ethoxy-2-phenyloxazole-4-carboxylic acid

: 88584-27-4
5-Ethoxy-2-phenyl-oxazole-4-carboxylic acid 1-amino-1-phenyl-meth-(E)-ylideneamide

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / oxalyl chloride, DMF / CH₂Cl₂; diethyl ether / 2 h / Ambient temperature

2: 72 percent / aq. NaOH / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In diethyl ether; dichloromethane;
DOI:10.1055/s-1983-30535