Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, (R)-

Base Information

Chemical Name:Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, (R)-
CAS No.:88588-30-1
Molecular Formula:C12H16O3
Molecular Weight:208.257
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, (R)-

There total 4 articles about Benzeneacetic acid, 4-methoxy-a-(1-methylethyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 33131-46-3
2-(4-methoxyphenyl)-3-methylcrotonic acid

: 88588-30-1
(2R)-2-(4-methoxyphenyl)-3-methylbutanoic acid

Guidance literature:: With (Sa,S)-[(C₈H₁₂)Ir(P(3,5-(tert-butyl)2C₆H₃)2C₈H₇CC₈H₇C₃NOH₃(benzyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; triethylamine; In methanol; at 60 ℃; for 20h; under 4560.31 Torr; enantioselective reaction; Autoclave; Inert atmosphere;
DOI:10.1021/ol401593a

Reference yield:

: 33131-46-3
2-(4-methoxyphenyl)-3-methylcrotonic acid

: 55332-36-0
(S)-2-(4-methoxyphenyl)-3-methylbutyric acid

: 88588-30-1
(2R)-2-(4-methoxyphenyl)-3-methylbutanoic acid

Guidance literature:: With silver tetrafluoroborate; (S)-cyclohexyl-BINAP; hydrogen; triethylamine; rhodium(I) chloride; In methanol; at 25 ℃; for 24h; under 38000 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 88588-30-1
(2R)-2-(4-methoxyphenyl)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.5 h / 25 - 40 °C / Inert atmosphere; Schlenk technique

1.2: Cooling with ice

2.1: triethylamine; hydrogen; (Sa,S)-[(C₈H₁₂)Ir(P(3,5-(tert-butyl)2C₆H₃)2C₈H₇CC₈H₇C₃NOH₃(benzyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate] / methanol / 20 h / 60 °C / 4560.31 Torr / Autoclave; Inert atmosphere

With (Sa,S)-[(C₈H₁₂)Ir(P(3,5-(tert-butyl)2C₆H₃)2C₈H₇CC₈H₇C₃NOH₃(benzyl))][tetrakis[3,5-bis(trifluoromethyl)phenyl]borate]; hydrogen; isopropylmagnesium chloride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ol401593a