5-Amino-2-methoxyphenol

Base Information

• Chemical Name: 5-Amino-2-methoxyphenol
• CAS No.: 1687-53-2
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 29225000
• European Community (EC) Number: 216-873-8
• UNII: 27QG246JAK
• DSSTox Substance ID: DTXSID60168594
• Nikkaji Number: J80.288C
• Wikidata: Q72438797
• ChEMBL ID: CHEMBL4777229
• Mol file: 1687-53-2.mol

Synonyms:5-Amino-2-methoxyphenol;1687-53-2;3-Hydroxy-4-methoxyaniline;5-Aminoguaiacol;2-Methoxy-5-aminophenol;Phenol, 5-amino-2-methoxy-;3-Amino-6-methoxyphenol;5-amino-2-(methyloxy)phenol;(3-Hydroxy-4-methoxyphenyl)amine;EINECS 216-873-8;MFCD00010222;5-amino-2-methoxy-phenol;Guaiacol, 5-amino-;3-hydroxy4-methoxyaniline;5-amino-2-methoxy phenol;3-hydroxy-4-methoxylaniline;SCHEMBL94025;BIDD:GT0054;27QG246JAK;CHEMBL4777229;5-Amino-2-methoxyphenol, 98%;DTXSID60168594;AC8244;AKOS000121303;AM84582;AC-26234;AS-16098;SY007941;CS-0062543;FT-0620012;H0634;EN300-21251;A811013;J-010482;Z104494830;[(3S,5S,8R,9S,10S,13R,14S,17R)-5-acetoxy-10-formyl-14-hydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate

Chemical Property of 5-Amino-2-methoxyphenol

Chemical Property:

• Appearance/Colour: grey-brown to dark brown crystalline powder
• Vapor Pressure: 0.00103mmHg at 25°C
• Melting Point: 130-132 °C(lit.)
• Refractive Index: 1.599
• Boiling Point: 292.7 °C at 760 mmHg
• PKA: 10.02±0.10(Predicted)
• Flash Point: 130.8 °C
• PSA: 55.48000
• Density: 1.219 g/cm³
• LogP: 1.56420
• Storage Temp.: Store below +30°C.
• Solubility.: slightly soluble
• Water Solubility.: slightly soluble
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-5-aminophenol 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-20/22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)N)O

Technology Process of 5-Amino-2-methoxyphenol

There total 5 articles about 5-Amino-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-nitroguaiacol (636-93-1) → 5-amino-2-methoxyphenol (1687-53-2)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 24h; under 2068.65 Torr;

Reference yield: 35.0%

5-amino-2-methoxyphenyl acetate (53606-43-2) → 5-amino-2-methoxyphenol (1687-53-2)

Guidance literature:

With sodium hydroxide;

Reference yield:

2-methoxy-5-nitrophenyl acetate (53606-41-0) → 5-amino-2-methoxyphenol (1687-53-2)

Guidance literature:

With hydrogenchloride; tin; at 60 ℃; unter Lichtausschluss;

upstream raw materials:

5-nitroguaiacol

2-methoxy-5-nitrophenyl acetate

5-amino-2-methoxyphenyl acetate

N-(5-hydroxypentyl)-2-hydroxy-1-methoxy-4-aminobenzene

Downstream raw materials:

N-(3-hydroxy-4-methoxyphenyl)acetamide

3-hydroxy-4-methoxyisonitrosoacetanilide

5-methylcyclohexanone-1,2-dione-1'-(3'-hydroxy-4'-methoxy)phenylhydrazone

5-bromo-2-methoxyphenol