Phenol, 3-ethyl-5-methoxy-

Base Information

• Chemical Name: Phenol, 3-ethyl-5-methoxy-
• CAS No.: 88640-66-8
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.193
• Mol file: 88640-66-8.mol

Synonyms:

Chemical Property of Phenol, 3-ethyl-5-methoxy-

Chemical Property:

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 3-ethyl-5-methoxy-

There total 4 articles about Phenol, 3-ethyl-5-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethoxybenzoic acid (1132-21-4) → 3-ethyl-5-methoxy-phenol (88640-66-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / (COCl)2 / benzene / 2 h, room t., 1 h, reflux

2: 70 percent / NaOAc, H₂ / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight

3: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux

4: hydrogen, conc. H₂SO₄ / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature

5: ethanethiol, NaH / dimethylformamide / 3 h / Heating

With oxalyl dichloride; sulfuric acid; hydrogen; sodium acetate; sodium hydride; magnesium; ethanethiol; methyl iodide; palladium on activated charcoal; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0031-9422(00)80159-4

Reference yield:

3,5-dimethoxybenzoyl chloride (17213-57-9) → 3-ethyl-5-methoxy-phenol (88640-66-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / NaOAc, H₂ / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight

2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux

3: hydrogen, conc. H₂SO₄ / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature

4: ethanethiol, NaH / dimethylformamide / 3 h / Heating

With sulfuric acid; hydrogen; sodium acetate; sodium hydride; magnesium; ethanethiol; methyl iodide; palladium on activated charcoal; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0031-9422(00)80159-4

Reference yield:

rac-1-(3,5-dimethoxyphenyl)ethan-1-ol (14950-55-1) → 3-ethyl-5-methoxy-phenol (88640-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen, conc. H₂SO₄ / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature

2: ethanethiol, NaH / dimethylformamide / 3 h / Heating

With sulfuric acid; hydrogen; sodium hydride; ethanethiol; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0031-9422(00)80159-4

upstream raw materials:

1,3-dimethoxy-5-ethylbenzene

rac-1-(3,5-dimethoxyphenyl)ethan-1-ol

3,5-dimethoxybenzoic acid

3,5-dimethoxybenzoyl chloride

Downstream raw materials:

[2-(2-ethyl-5-methoxy-phenoxy)-ethyl]-dimethyl-amine