Methyl 3-(aminomethyl)-5-fluorobenzoate HCl

Base Information

• Chemical Name: Methyl 3-(aminomethyl)-5-fluorobenzoate HCl
• CAS No.: 886732-31-6
• Molecular Formula: C9H10FNO2
• Molecular Weight: 183.182
• Mol file: 886732-31-6.mol

Synonyms:3-aminomethyl-5-fluorobenzoic acid methyl ester;Methyl3-(aminomethyl)-5-fluorobenzoateHCl;

Chemical Property of Methyl 3-(aminomethyl)-5-fluorobenzoate HCl

Chemical Property:

• PSA: 52.32000
• LogP: 1.77130

Purity/Quality:

99%, ^*data from raw suppliers

3-Aminomethyl-5-fluorobenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Aminomethyl-5-fluorobenzoic Acid Methyl Ester is an intermediate used to prepare N-benzyl sulfonamides as 11β-HSD1 inhibitors.

Technology Process of Methyl 3-(aminomethyl)-5-fluorobenzoate HCl

There total 3 articles about Methyl 3-(aminomethyl)-5-fluorobenzoate HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-(tert-butoxycarbonylaminomethyl)-5-fluorobenzoic acid methyl ester (886732-30-5) → methyl 3-(aminomethyl)-5-fluorobenzoate (886732-31-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 4.5h;

Reference yield:

methyl 3-cyano-5-fluorobenzoate (886732-29-2) → methyl 3-(aminomethyl)-5-fluorobenzoate (886732-31-6)

Guidance literature:

With ammonia; hydrogen; In methanol; at 25 ℃; for 16h; under 2585.81 Torr;

Reference yield:

3-cyano-5-fluorobenzoic acid (327056-74-6) → methyl 3-(aminomethyl)-5-fluorobenzoate (886732-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / dichloromethane / 2 h / 25 °C

2: hydrogen; ammonia / methanol / 16 h / 25 °C / 2585.81 Torr

With methanol; ammonia; hydrogen; In methanol; dichloromethane;

upstream raw materials:

3-(tert-butoxycarbonylaminomethyl)-5-fluorobenzoic acid methyl ester

3-cyano-5-fluorobenzoic acid

methyl 3-cyano-5-fluorobenzoate