18-vinylprogesterone

Base Information

Chemical Name:18-vinylprogesterone
CAS No.:80899-87-2
Molecular Formula:C₂₃H₃₀O₂
Molecular Weight:338.49
Hs Code.:
Mol file:80899-87-2.mol

Synonyms:18-ethynyl-pregn-4-ene-3,20-dione;18-ethynylpregn-4-ene-3,20-dione;(8S,9S,10R,13R,14S,17S)-17-Acetyl-10-methyl-13-prop-2-ynyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one;

Suppliers and Price of 18-vinylprogesterone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 18-vinylprogesterone

Chemical Property:

Vapor Pressure:3.22E-09mmHg at 25°C
Boiling Point:475.8°Cat760mmHg
Flash Point:176.6°C
PSA：34.14000
Density:1.1g/cm³
LogP:4.72690

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 18-vinylprogesterone

There total 4 articles about 18-vinylprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 115910-67-3
18-ethynyl-20,20-ethylenedioxy-pregn-4-ene-3-one

: 80899-87-2
18-ethynyl-pregn-4-ene-3,20-dione

Guidance literature:: With IRN-77 Amberlite; In acetone; at 20 ℃;
DOI:10.1016/S0040-4020(01)85892-0

Reference yield:

: 115884-45-2,115884-46-3
3β-tertiobutyldimethylsilyloxy-18-chlorovinyl-20,20-ethylenedioxy-pregn-5-ene

: 80899-87-2
18-ethynyl-pregn-4-ene-3,20-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium, ammonia / 1.) ferrous nitrate / 1.) THF, -50 deg C, 1 h; 2.) THF, 3 h, -33 deg C

2: 70 percent / 1.0 M tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

3: 1.) N-methyl piperidone; 2.) aluminium isopropoxide / 1.) toluene, reflux; 2.) toluene, reflux, 5 h

4: 84 percent / IRN-77 Amberlite / acetone / 20 °C

With 1-methylpiperidin-2-one; IRN-77 Amberlite; tetrabutyl ammonium fluoride; ammonia; sodium; aluminum isopropoxide; iron(II) nitrate; In tetrahydrofuran; acetone;
DOI:10.1016/S0040-4020(01)85892-0

Reference yield:

: 115884-49-6
3β-hydroxy-18-ethynyl-20,20-ethylenedioxy-pregn-5-ene

: 80899-87-2
18-ethynyl-pregn-4-ene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) N-methyl piperidone; 2.) aluminium isopropoxide / 1.) toluene, reflux; 2.) toluene, reflux, 5 h

2: 84 percent / IRN-77 Amberlite / acetone / 20 °C

With 1-methylpiperidin-2-one; IRN-77 Amberlite; aluminum isopropoxide; In acetone;
DOI:10.1016/S0040-4020(01)85892-0