2-((4-Methoxyphenyl)thio)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-((4-Methoxyphenyl)thio)isoindoline-1,3-dione
• CAS No.: 88683-45-8
• Molecular Formula: C15H11NO3S
• Molecular Weight: 285.323
• DSSTox Substance ID: DTXSID70512185
• Nikkaji Number: J2.286.580C
• Wikidata: Q82371320

Synonyms:2-((4-Methoxyphenyl)thio)isoindoline-1,3-dione;88683-45-8;SCHEMBL16694595;DTXSID70512185;N-(p-Methoxyphenylsulfanyl)phthalimide;2-[(4-Methoxyphenyl)sulfanyl]-1H-isoindole-1,3(2H)-dione

Chemical Property of 2-((4-Methoxyphenyl)thio)isoindoline-1,3-dione

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 285.04596439
• Heavy Atom Count: 20
• Complexity: 369

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)SN2C(=O)C3=CC=CC=C3C2=O

Technology Process of 2-((4-Methoxyphenyl)thio)isoindoline-1,3-dione

There total 3 articles about 2-((4-Methoxyphenyl)thio)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-bromo-4-methoxy-benzene (104-92-7) + phthalimidesulfenyl chloride (54974-07-1) → 2-((4-methoxyphenyl)thio)isoindoline-1,3-dione (88683-45-8)

Guidance literature:

1-bromo-4-methoxy-benzene; With iodine; magnesium; lithium chloride; In tetrahydrofuran; at 55 ℃; for 2.5h; Inert atmosphere; Schlenk technique;

With zinc(II) chloride; In tetrahydrofuran; at 0 - 25 ℃; for 1h; Inert atmosphere; Schlenk technique;

phthalimidesulfenyl chloride; In tetrahydrofuran; dichloromethane; at 0 - 25 ℃; for 0.833333h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.202009699

Reference yield:

phthalimide (136918-14-4,85-41-6) → 2-((4-methoxyphenyl)thio)isoindoline-1,3-dione (88683-45-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: disulfur dichloride; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: sulfuryl dichloride; pyridine / dichloromethane / 48 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: magnesium; lithium chloride; iodine / tetrahydrofuran / 2.5 h / 55 °C / Inert atmosphere; Schlenk technique

3.2: 1 h / 0 - 25 °C / Inert atmosphere; Schlenk technique

3.3: 0.83 h / 0 - 25 °C / Inert atmosphere; Schlenk technique

With pyridine; disulfur dichloride; sulfuryl dichloride; iodine; magnesium; triethylamine; lithium chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.202009699

Reference yield:

4,4'-dimethoxyphenyl thiosulfonate (1153-43-1) → 2-((4-methoxyphenyl)thio)isoindoline-1,3-dione (88683-45-8)

Guidance literature:

With tetrachloromethane; chlorine; Beim Behandeln des Reaktionsprodukts in Aether mit Kaliumphthalimid;

upstream raw materials:

4,4'-dimethoxyphenyl thiosulfonate

phthalimide

1-bromo-4-methoxy-benzene

phthalimidesulfenyl chloride

Downstream raw materials:

C₁₅H₁₉NOS

2-(4-Methoxyphenylthio)pyrrole

C₁₆H₁₉NO₃S

C₂₁H₂₁NO₃S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 88683-45-8 1H-Isoindole-1,3(2H)-dione, 2-[(4-methoxyphenyl)thio]-

Send

Send

Metric Ton KG G Pound L ML

Send

Send