cis-4'-Fluoro-4-((4-methoxy-4-p-tolylcyclohexyl)amino)butyrophenone hydrochloride

Base Information

Chemical Name:cis-4'-Fluoro-4-((4-methoxy-4-p-tolylcyclohexyl)amino)butyrophenone hydrochloride
CAS No.:42020-71-3
Molecular Formula:C24H31ClFNO2
Molecular Weight:419.9598
Hs Code.:
DSSTox Substance ID:DTXSID50962169
Mol file:42020-71-3.mol

Synonyms:cis-4'-Fluoro-4-((4-methoxy-4-p-tolylcyclohexyl)amino)butyrophenone hydrochloride;Butyrophenone, 4'-fluoro-4-((4-methoxy-4-p-tolylcyclohexyl)amino)-, hydrochlroide, (Z)-;cis-N-(3-(p-Fluorobenzoyl)propyl)-4-methoxy-4-p-tolylcyclohexylamine hydrochloride;42020-71-3;C24H30FNO2.ClH;SCHEMBL11802217;SCHEMBL11802226;SCHEMBL11803814;DTXSID50962169;LS-48396;1-(4-Fluorophenyl)-4-{[4-methoxy-4-(4-methylphenyl)cyclohexyl]amino}butan-1-one--hydrogen chloride (1/1);1-Butanone, 1-(4-fluorophenyl)-4-[[4-methoxy-4-(4-methylphenyl)cyclohexyl]amino]-, hydrochloride, cis-

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-4'-Fluoro-4-((4-methoxy-4-p-tolylcyclohexyl)amino)butyrophenone hydrochloride

Chemical Property:

Vapor Pressure:5.8E-11mmHg at 25°C
Boiling Point:521.2°Cat760mmHg
Flash Point:269°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:419.2027351
Heavy Atom Count:29
Complexity:473

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2(CCC(CC2)NCCCC(=O)C3=CC=C(C=C3)F)OC.Cl

Technology Process of cis-4'-Fluoro-4-((4-methoxy-4-p-tolylcyclohexyl)amino)butyrophenone hydrochloride

There total 4 articles about cis-4'-Fluoro-4-((4-methoxy-4-p-tolylcyclohexyl)amino)butyrophenone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,2-dimethyl-1,3-propanediol ketal of 4-chloro-4'-fluorobutyrophenone

: 42020-61-1,42020-89-3
4-cis-methoxy-4-trans-(p-methylphenyl)-cyclohexylamine hydrochloride

: 42020-71-3
4'-fluoro-4-{[4-trans-methoxy-4-cis-(p-methylphenyl)cyclohexyl]amino}butyrophenone hydrochloride

Guidance literature:: With hydrogenchloride; potassium iodide; potassium carbonate; In N-methyl-acetamide; methanol; water;

Reference yield:

: 4-trans-methoxy-4-cis-(p-methylphenyl)-cyclohexan-1-ylazide

: 42020-71-3
4'-fluoro-4-{[4-trans-methoxy-4-cis-(p-methylphenyl)cyclohexyl]amino}butyrophenone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; sodium hydroxide / tetrahydrofuran; water

2: hydrogenchloride; potassium iodide; potassium carbonate / N-methyl-acetamide; methanol; water

With hydrogenchloride; sodium hydroxide; potassium iodide; potassium carbonate; In tetrahydrofuran; N-methyl-acetamide; methanol; water;

Reference yield:

: 4-cis-methoxy-4-trans-(p-methylphenyl)-cyclohexanol methanesulfonate

: 42020-71-3
4'-fluoro-4-{[4-trans-methoxy-4-cis-(p-methylphenyl)cyclohexyl]amino}butyrophenone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: N-methyl-acetamide; benzene

2: hydrogenchloride; sodium hydroxide / tetrahydrofuran; water

3: hydrogenchloride; potassium iodide; potassium carbonate / N-methyl-acetamide; methanol; water

With hydrogenchloride; sodium hydroxide; potassium iodide; potassium carbonate; In tetrahydrofuran; N-methyl-acetamide; methanol; water; benzene;