Corydalmine

Base Information

Chemical Name:Corydalmine
CAS No.:30413-84-4
Molecular Formula:C₂₀H₂₃NO₄
Molecular Weight:341.407
Hs Code.:
UNII:DV8DX4568D
DSSTox Substance ID:DTXSID40952751
Nikkaji Number:J884.411I
Wikidata:Q72461550
Pharos Ligand ID:291W55GN7KA8
Metabolomics Workbench ID:134678
ChEMBL ID:CHEMBL448891
Mol file:30413-84-4.mol

Synonyms:corydalmine;corydalmine, (13R-trans)-isomer

Suppliers and Price of Corydalmine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Arctom
Corydalmine ≥98%
5mg
$ 513.00

Total 22 raw suppliers

Chemical Property of Corydalmine

Chemical Property:

Vapor Pressure:1.14E-10mmHg at 25°C
Melting Point:177-178℃
Boiling Point:501.2oC at 760 mmHg
PKA:9.97±0.20(Predicted)
Flash Point:256.9oC
PSA：51.16000
Density:1.29g/cm3
LogP:3.01140
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:341.16270821
Heavy Atom Count:25
Complexity:461

Purity/Quality:

99%, ^*data from raw suppliers

Corydalmine ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)OC
Isomeric SMILES:COC1=C(C=C2[C@@H]3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)OC

Technology Process of Corydalmine

There total 31 articles about Corydalmine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1422431-58-0
(S)-10-(benzyloxy)-2,3,9-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline

: 30413-84-4
(-)-corydalmine

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 15h; under 750.075 - 4500.45 Torr; Reagent/catalyst; Temperature; Solvent; Inert atmosphere; Autoclave;

Reference yield:

: 1422431-58-0
(S)-10-(benzyloxy)-2,3,9-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline

: 6877-26-5
C₂₀H₂₃NO₄

: 30413-84-4
(-)-corydalmine

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; In methanol; ethyl acetate; at 15 - 30 ℃; Reagent/catalyst; Temperature; Overall yield = 85 percent; Optical yield = 80 percent ee;

Reference yield:

: (S)-1-(4-(benzyloxy)-2-(chloromethyl)-3-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrakis hydroisoquinoline

: 30413-84-4
(-)-corydalmine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C

2: hydrogenchloride / water; ethanol / 2 h / Reflux

With hydrogenchloride; sodium hydrogencarbonate; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2012.12.016