Senkyunolide I

Base Information

• Chemical Name: Senkyunolide I
• CAS No.: 94596-28-8
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 94596-28-8.mol

Synonyms:1(3H)-Isobenzofuranone,3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-, (3Z,6a,7b)-; Senkyunolide I

Chemical Property of Senkyunolide I

Chemical Property:

• PSA: 66.76000
• Density: 1.28
• LogP: 1.03940

Purity/Quality:

99%, ^*data from raw suppliers

Senkyunolide I ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Senkyunolide I is a bioactive phthalide isolated from the root and stem exteriors of Angelica sinensis. An anti-migraine compound.

Technology Process of Senkyunolide I

There total 7 articles about Senkyunolide I which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-ligustilide (81944-09-4) → senkyunolide-I (874142-56-0,153609-96-2,796865-76-4) + senkyunolide-H (88551-87-5,93379-53-4,94596-27-7,94596-28-8,153609-96-2,796865-76-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 0.0333333h; Heating;

DOI:10.1248/cpb.35.1427

Reference yield:

Z-ligustilide (81944-09-4) → cis-6,7-dihydroxyligustilide (88551-87-5,93379-53-4,94596-27-7,94596-28-8,153609-96-2,796865-76-4) + trans-6,7-dihydroxyligustilide (88551-87-5,93379-53-4,94596-27-7,94596-28-8,153609-96-2,796865-76-4)

Guidance literature:

With water; 3-chloro-benzenecarboperoxoic acid; 1.) methylene chloride;

DOI:10.1248/cpb.32.3770

Reference yield:

Z-ligustilide (81944-09-4) → cis-6,7-dihydroxyligustilide (88551-87-5,93379-53-4,94596-27-7,94596-28-8,153609-96-2,796865-76-4) + trans-6,7-dihydroxyligustilide (88551-87-5,93379-53-4,94596-27-7,94596-28-8,153609-96-2,796865-76-4)

Guidance literature:

With water; 3-chloro-benzenecarboperoxoic acid; 1.) methylene chloride;

DOI:10.1248/cpb.32.3770

upstream raw materials:

Z-ligustilide

senkyunolide-G

Refernces

• 1、 Kobayashi,Fujita,Mitsuhashi. "Studies on the constituents of umbelliferae plants. XV. Constituents of Cnidium officinale: Occurrence of pregnenolone, coniferylferulate and hydroxyphthalides". . p. 1427 - 1433. Retrieved 2007/10/02.