2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole

Base Information

Chemical Name:2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole
CAS No.:887625-50-5
Molecular Formula:C9H4BrF2NS
Molecular Weight:276.104
Hs Code.:
DSSTox Substance ID:DTXSID20702953
Wikidata:Q82634991
Mol file:887625-50-5.mol

Synonyms:2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole;SCHEMBL3766113;DTXSID20702953;VNFBEKOOMQAMEY-UHFFFAOYSA-N;887625-50-5

Suppliers and Price of 2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-BROMO-4-(2,4-DIFLUOROPHENYL)THIAZOLE 95.00%
5MG
$ 499.53

Total 2 raw suppliers

Chemical Property of 2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole

Chemical Property:

PSA：41.13000
LogP:3.85080
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:274.92159
Heavy Atom Count:14
Complexity:207

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

2-BROMO-4-(2,4-DIFLUOROPHENYL)THIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)F)C2=CSC(=N2)Br

Technology Process of 2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole

There total 2 articles about 2-Bromo-4-(2,4-difluorophenyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 887625-49-2
1-(2,4-difluorophenyl)-2-thiocyanatoethanone

: 887625-50-5
2-bromo-4-(2,4-difluorophenyl)thiazole

Guidance literature:: With hydrogen bromide; In acetic acid; at 130 ℃; for 3h;
DOI:10.1016/j.bmc.2012.11.006

Reference yield:

: 102429-07-2
2-bromo-2',4'-difluoroacetophenone

: 887625-50-5
2-bromo-4-(2,4-difluorophenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 3 h / 80 °C

2: hydrogen bromide / acetic acid / 3 h / 130 °C

With hydrogen bromide; In ethanol; acetic acid;
DOI:10.1016/j.bmc.2012.11.006