N-(2-(N-Ethyl-m-toluidino)ethyl)phthalimide

Base Information

• Chemical Name: N-(2-(N-Ethyl-m-toluidino)ethyl)phthalimide
• CAS No.: 2498-02-4
• Molecular Formula: C19H20 N2 O2
• Molecular Weight: 308.38
• European Community (EC) Number: 219-685-4
• UNII: 82A4CW4H3K
• DSSTox Substance ID: DTXSID5062471
• Nikkaji Number: J191.989J
• Wikidata: Q81990058
• Mol file: 2498-02-4.mol

Synonyms:2498-02-4;N-(2-(N-Ethyl-m-toluidino)ethyl)phthalimide;82A4CW4H3K;1H-Isoindole-1,3(2H)-dione, 2-(2-(ethyl(3-methylphenyl)amino)ethyl)-;1H-Isoindole-1,3(2H)-dione, 2-[2-[ethyl(3-methylphenyl)amino]ethyl]-;2-[2-[Ethyl(3-methylphenyl)amino]ethyl]-1H-isoindole-1,3(2H)-dione;2-(2-(ETHYL(3-METHYLPHENYL)AMINO)ETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE;EINECS 219-685-4;UNII-82A4CW4H3K;DTXSID5062471;SCHEMBL11082723

Chemical Property of N-(2-(N-Ethyl-m-toluidino)ethyl)phthalimide

Chemical Property:

• Vapor Pressure: 5.17E-09mmHg at 25°C
• Boiling Point: 470.2°Cat760mmHg
• Flash Point: 205.1°C
• PSA: 40.62000
• Density: 1.207g/cm³
• LogP: 3.05540
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 308.152477885
• Heavy Atom Count: 23
• Complexity: 427

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CCN1C(=O)C2=CC=CC=C2C1=O)C3=CC=CC(=C3)C

Technology Process of N-(2-(N-Ethyl-m-toluidino)ethyl)phthalimide

There total 4 articles about N-(2-(N-Ethyl-m-toluidino)ethyl)phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-ethyl-N-(2-hydroxyethyl)-3-methylaniline (91-88-3) → N-[2-(N-ethyl-m-toluidino)-ethyl]-phthalimide (2498-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: 180 °C

With trichlorophosphate;

DOI:10.1021/ja01151a037

Reference yield:

N-ethyl-m-toulidine (102-27-2) → N-[2-(N-ethyl-m-toluidino)-ethyl]-phthalimide (2498-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 130 - 135 °C

2: POCl₃

3: 180 °C

With trichlorophosphate;

DOI:10.1021/ja01151a037

Reference yield:

potassium phtalimide (1074-82-4) + N-(2-chloro-ethyl)-N-ethyl-3-methyl-aniline (22564-43-8) → N-[2-(N-ethyl-m-toluidino)-ethyl]-phthalimide (2498-02-4)

Guidance literature:

at 180 ℃;

DOI:10.1021/ja01151a037

upstream raw materials:

potassium phtalimide

N-(2-chloro-ethyl)-N-ethyl-3-methyl-aniline

N-ethyl-N-(2-hydroxyethyl)-3-methylaniline

N-ethyl-m-toulidine

Downstream raw materials:

N₁-ethyl-N₁-(3-methylphenyl)-1,2-ethanediamine

N-[2-(N-ethyl-m-toluidino)-ethyl]-methanesulfonamide