Technology Process of Phosphine oxide,
[2-[5-(1-ethoxyethoxy)-2-methylenecyclohexylidene]ethyl]diphenyl-, (E)-
There total 11 articles about Phosphine oxide,
[2-[5-(1-ethoxyethoxy)-2-methylenecyclohexylidene]ethyl]diphenyl-, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium diisopropyl amide;
In
tetrahydrofuran;
-78 deg C, 15 min then -20 deg C, 16 h;
DOI:10.1016/S0040-4020(01)91875-7
- Guidance literature:
-
Multi-step reaction with 6 steps
2: 2) NaBr / 1) pyridine, 1 h, room temperature 2) DMF, 80-85 deg C, 2 h
3: 2) 5percent H2O2 / 1) THF, -20 deg C then room temperature 16 h, quenching with sat. NH4Cl solution 2) CHCl3, 1 h, room temperature
4: 72 percent / 10percent NaOH / methanol / 8 h / Ambient temperature
5: 46 percent / toluene-p-sulfonic acid / CH2Cl2 / 1 h / Ambient temperature
6: 13 percent / lithium diisopropylamide / tetrahydrofuran / -78 deg C, 15 min then -20 deg C, 16 h
With
sodium hydroxide; dihydrogen peroxide; sodium bromide; lithium diisopropyl amide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)91875-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2) 5percent H2O2 / 1) THF, -20 deg C then room temperature 16 h, quenching with sat. NH4Cl solution 2) CHCl3, 1 h, room temperature
2: 72 percent / 10percent NaOH / methanol / 8 h / Ambient temperature
3: 46 percent / toluene-p-sulfonic acid / CH2Cl2 / 1 h / Ambient temperature
4: 13 percent / lithium diisopropylamide / tetrahydrofuran / -78 deg C, 15 min then -20 deg C, 16 h
With
sodium hydroxide; dihydrogen peroxide; lithium diisopropyl amide;
toluene-4-sulfonic acid;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)91875-7
