1,4-Bis(4-bromophenyl)butane-1,4-dione

Base Information

• Chemical Name: 1,4-Bis(4-bromophenyl)butane-1,4-dione
• CAS No.: 2461-83-8
• Molecular Formula: C16H12 Br2 O2
• Molecular Weight: 396.078
• Hs Code.: 2914700090
• Mol file: 2461-83-8.mol

Synonyms:1,4-Butanedione,1,4-bis(p-bromophenyl)- (6CI,7CI,8CI); 1,2-Bis(4-bromobenzoyl)ethane;1,4-Bis(4-bromophenyl)-1,4-butanedione; NSC 222

Chemical Property of 1,4-Bis(4-bromophenyl)butane-1,4-dione

Chemical Property:

• Vapor Pressure: 3.91E-10mmHg at 25°C
• Melting Point: 182 °C(Solv: benzene (71-43-2))
• Boiling Point: 500.1°C at 760 mmHg
• Flash Point: 141.6°C
• PSA: 34.14000
• Density: 1.611g/cm³
• LogP: 5.05740
• Storage Temp.: -20°C Freezer
• Solubility.: Dichloromethane, Methanol

Purity/Quality:

99%min ^*data from raw suppliers

1,4-Bis(4-bromophenyl)-1,4-butanedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1,4-Bis(4-bromophenyl)butane-1,4-dione is used in the preparation of Furamidine (F863600) an antimicrobial and antiparasitic agent.

Technology Process of 1,4-Bis(4-bromophenyl)butane-1,4-dione

There total 31 articles about 1,4-Bis(4-bromophenyl)butane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

para-bromophenacyl bromide (99-73-0,132309-76-3) → 1,4-bis(4-bromophenyl)-1,4-butanedione (2461-83-8)

Guidance literature:

With iodine; zinc; In tetrahydrofuran; for 16h; Heating;

DOI:10.1055/s-2004-829118

Reference yield: 94.0%

(E)-1,4-bis(4-bromophenyl)but-2-ene-1,4-dione (6332-09-8,34102-91-5,74322-80-8) → 1,4-bis(4-bromophenyl)-1,4-butanedione (2461-83-8)

Guidance literature:

With tin(II) chloride dihdyrate; acetic acid; In ethanol; for 0.333333h; Reflux;

DOI:10.1016/j.ejmech.2016.12.041

Reference yield: 87.0%

1-(4-bromo-phenyl)-2,2-dichloro-ethanone (7716-86-1) → 1,4-bis(4-bromophenyl)-1,4-butanedione (2461-83-8)

Guidance literature:

With indium(I) bromide; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1055/s-2004-825591

upstream raw materials:

1.4-bis-(4-bromo-phenyl)-butene-(2c)-dione-(1.4)

(E)-1,4-bis(4-bromophenyl)but-2-ene-1,4-dione

(Z)-1,4-bis(4-bromophenyl)-2,3-dichlorobut-2-ene-1,4-dione

2.3-dichloro-1.4-bis-(4-bromo-phenyl)-butene-(2t)-dione-(1.4)

Downstream raw materials:

[2,5-bis-(4-bromo-phenyl)-pyrrol-1-yl]-acetic acid

2,5-bis(4-bromophenyl)-1-phenyl-1H-pyrrole

2,5-bis(4-bromophenyl)furan

2,5-bis(4-bromophenyl)-1-(4-tert-butylphenyl)-1H-pyrrole

Refernces

• 1、 Jia, Wenqiang,Xi, Qiumu,Liu, Tianqi,Yang, Minjian,Chen, Yonghui,Yin, Dali,Wang, Xiaojian. "One-Pot Synthesis of O-Heterocycles or Aryl Ketones Using an InCl3/Et3SiH System by Switching the Solvent". . p. 5141 - 5149. Retrieved 2019/05/10.
• 2、 Chalikidi, Petrakis N.,Uchuskin, Maxim G.,Trushkov, Igor V.,Abaev, Vladimir T.,Serdyuk, Olga V.. "Facile Synthesis of β-Keto Sulfones Employing Fenton's Reagent in DMSO". supporting information. p. 571 - 575. Retrieved 2018/01/11.