Teverelix

Base Information

• Chemical Name: Teverelix
• CAS No.: 144743-92-0
• Deprecated CAS: 144743-92-0
• Molecular Formula: C₇₄H₁₀₀ClN₁₅O₁₄
• Molecular Weight: 1459.15
• UNII: D19V7048JK
• DSSTox Substance ID: DTXSID301033772
• Metabolomics Workbench ID: 149529
• NCI Thesaurus Code: C132277
• Nikkaji Number: J1.643.195H
• Wikidata: Q27275967
• Mol file: 144743-92-0.mol

Synonyms:Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Hci-Leu-Lys(iPr)-Pro-D-Ala-NH2;antarelix;EP 24332;EP-24332;teverelix;teverelix acetate

Chemical Property of Teverelix

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1692.9°Cat760mmHg
• Flash Point: 977.6°C
• PSA: 445.80000
• Density: 1.275g/cm³
• LogP: 7.42740
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 15
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 41
• Exact Mass: 1457.7262706
• Heavy Atom Count: 104
• Complexity: 2810

Purity/Quality:

TEVERELIX 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(=O)N)NC(=O)C(CCCCNC(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CN=CC=C3)NC(=O)C(CC4=CC=C(C=C4)Cl)NC(=O)C(CC5=CC6=CC=CC=C6C=C5)NC(=O)C
• Isomeric SMILES: C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(=O)N)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC3=CN=CC=C3)NC(=O)[C@@H](CC4=CC=C(C=C4)Cl)NC(=O)[C@@H](CC5=CC6=CC=CC=C6C=C5)NC(=O)C
• Recent EU Clinical Trials: A Phase II single centre, open-label study investigating the pharmacokinetics, pharmacodynamics, efficacy and safety of a loading dose regimen of a new GnRH antagonist, Teverelix, long-acting formulation administered subcutaneously as two doses of 120 mg (given as 2 injections of 60 mg on Day 1 and repeated on Day 2) in patients with advanced prostate cancer