1H-Indene-2-carboxylic acid, 4-[[(2R,6S)-2,6-dimethyl-4-[4-(trifluoromethoxy)phenyl]-1-piperazinyl]sulf onyl]-2,3-dihydro-, methyl ester, rel-

Base Information

Chemical Name:1H-Indene-2-carboxylic acid, 4-[[(2R,6S)-2,6-dimethyl-4-[4-(trifluoromethoxy)phenyl]-1-piperazinyl]sulf onyl]-2,3-dihydro-, methyl ester, rel-
CAS No.:888327-31-9
Molecular Formula:C24H27F3N2O5S
Molecular Weight:512.55
Hs Code.:

1H-Indene-2-carboxylic acid,
4-[[(2R,6S)-2,6-dimethyl-4-[4-(trifluoromethoxy)phenyl]-1-piperazinyl]sulf
onyl]-2,3-dihydro-, methyl ester, rel-

Synonyms:

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Chemical Property of 1H-Indene-2-carboxylic acid, 4-[[(2R,6S)-2,6-dimethyl-4-[4-(trifluoromethoxy)phenyl]-1-piperazinyl]sulf onyl]-2,3-dihydro-, methyl ester, rel-

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Technology Process of 1H-Indene-2-carboxylic acid, 4-[[(2R,6S)-2,6-dimethyl-4-[4-(trifluoromethoxy)phenyl]-1-piperazinyl]sulf onyl]-2,3-dihydro-, methyl ester, rel-

There total 2 articles about 1H-Indene-2-carboxylic acid, 4-[[(2R,6S)-2,6-dimethyl-4-[4-(trifluoromethoxy)phenyl]-1-piperazinyl]sulf onyl]-2,3-dihydro-, methyl ester, rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 888327-29-5
(RS)-4-chlorosulfonyl-indan-2-carboxylic acid methyl ester

: 866787-30-6
3,5-dimethyl-1-(4-trifluoromethoxy-phenyl)-piperazine

: 888327-31-9
(RS)-4-[cis-2,6-dimethyl-4-(4-trifluoromethoxy-phenyl)-piperazine-1-sulfonyl]-indan-2-carboxylic acid methyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; at 60 ℃; for 20h;

Reference yield:

: 909793-64-2
(R,S)-4-chlorosulfonyl-indan-2-carboxylic acid

: 934760-93-7
cis-3,5-dimethyl-1-(4-trifluoromethoxy-phenyl)-piperazine hydrochloride

: 888327-31-9
(RS)-4-[cis-2,6-dimethyl-4-(4-trifluoromethoxy-phenyl)-piperazine-1-sulfonyl]-indan-2-carboxylic acid methyl ester

Guidance literature:: cis-3,5-dimethyl-1-(4-trifluoromethoxy-phenyl)-piperazine hydrochloride; In dichloromethane; water; at 20 ℃;

(R,S)-4-chlorosulfonyl-indan-2-carboxylic acid; With potassium carbonate; In acetonitrile; at 50 ℃; Product distribution / selectivity;

Reference yield: 93.0%

: 888327-31-9
(RS)-4-[cis-2,6-dimethyl-4-(4-trifluoromethoxy-phenyl)-piperazine-1-sulfonyl]-indan-2-carboxylic acid methyl ester

: 4-[cis-2,6-dimethyl-4-(4-trifluoromethoxy-phenyl)-piperazine-1-sulfonyl]-indan-2-carboxylic acid

Guidance literature:: (RS)-4-[cis-2,6-dimethyl-4-(4-trifluoromethoxy-phenyl)-piperazine-1-sulfonyl]-indan-2-carboxylic acid methyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; In water;