Acetamide, N-(6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido(6,1-a)isoquinolin-2-yl)-N-(2,4,6-trimethylphenyl)-

Base Information

Chemical Name:Acetamide, N-(6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido(6,1-a)isoquinolin-2-yl)-N-(2,4,6-trimethylphenyl)-
CAS No.:83070-40-0
Molecular Formula:C₂₅H₂₇N₃O₄
Molecular Weight:433.507
Hs Code.:
DSSTox Substance ID:DTXSID10232153
Wikidata:Q83113185
ChEMBL ID:CHEMBL417139

Synonyms:BRN 5664028;Acetamide, N-(6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido(6,1-a)isoquinolin-2-yl)-N-(2,4,6-trimethylphenyl)-;83070-40-0;CHEMBL417139;SCHEMBL7332222;DTXSID10232153;PVAKQAGZUGLINZ-UHFFFAOYSA-N;C25H27N3O4;C25-H27-N3-O4;LS-9172;9,10-dimethoxy-2-(N-acetyl-2,4,6-trimethylanilino)-6,7-dihydro-4H-pyrimido-(6,1-a)isoquinolin-4-one;9,10-dimethoxy-2-(N-acetyl-2,4,6-trimethylanilino)-6,7-dihydro-4H-pyrimido-(6,1-a)isoquinolin-4one

Suppliers and Price of Acetamide, N-(6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido(6,1-a)isoquinolin-2-yl)-N-(2,4,6-trimethylphenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Acetamide, N-(6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido(6,1-a)isoquinolin-2-yl)-N-(2,4,6-trimethylphenyl)-

Chemical Property:

Vapor Pressure:7.2E-15mmHg at 25°C
Boiling Point:611°Cat760mmHg
Flash Point:323.3°C
Density:1.24g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:433.20015635
Heavy Atom Count:32
Complexity:797

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C(=C1)C)N(C2=NC(=O)N3CCC4=CC(=C(C=C4C3=C2)OC)OC)C(=O)C)C

Technology Process of Acetamide, N-(6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido(6,1-a)isoquinolin-2-yl)-N-(2,4,6-trimethylphenyl)-

There total 6 articles about Acetamide, N-(6,7-dihydro-9,10-dimethoxy-4-oxo-4H-pyrimido(6,1-a)isoquinolin-2-yl)-N-(2,4,6-trimethylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76536-66-8
9,10-dimethoxy-2-(2,4,6-trimethylanilino)-6,7-dihydro-4H-pyrimido(6,1-a)isoquinolin-4-one

: 83070-40-0
9,10-dimethoxy-2-(N-acetyl-2,4,6-trimethylanilino)-6,7-dihydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Heating;
DOI:10.1021/jm00377a016

Reference yield:

: 25017-47-4
N-<2-(3,4-dimethoxyphenylethyl)>urea

: 83070-40-0
9,10-dimethoxy-2-(N-acetyl-2,4,6-trimethylanilino)-6,7-dihydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / EtONa / ethanol / 16 h / Heating

2: 100 percent / POCl₃ / 2.5 h / 100 - 110 °C

3: 74 percent / CHCl₃ / 20 h / Heating

4: NaH / dimethylformamide / Heating

With sodium ethanolate; sodium hydride; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00377a016

Reference yield:

: 91209-74-4
1-(carbamoylmethylene)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 83070-40-0
9,10-dimethoxy-2-(N-acetyl-2,4,6-trimethylanilino)-6,7-dihydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / EtONa / ethanol / 8 h / Heating

2: 87 percent / POCl₃ / 4 h / 110 °C

3: 74 percent / CHCl₃ / 20 h / Heating

4: NaH / dimethylformamide / Heating

With sodium ethanolate; sodium hydride; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00377a016