Technology Process of L-Glutamic acid,
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-,
1-[(2,6-dichlorophenyl)methyl] 5-hexadecyl ester
There total 9 articles about L-Glutamic acid,
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-,
1-[(2,6-dichlorophenyl)methyl] 5-hexadecyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate;
In
N,N-dimethyl-formamide;
for 2.5h;
Ambient temperature;
DOI:10.1021/jm00371a009
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / Cs2CO2 / dimethylformamide / 60 h / Ambient temperature
2: 92 percent / H2 / 5percent Pd/C / propan-2-ol / 1520 - 2280 Torr / Ambient temperature
3: 100 percent / DCC, pyridine / acetonitrile; dimethylformamide / 1 h / 0 °C
4: 100 percent / benzene / 1 h / Heating
5: 1.) diethyl phosphorocyanidate, Et3N / 1.) DMF, 80 deg C, 2 min, 2.) DMF, 80 deg C, 2 h
6: 53 percent / tetrabutylammonium chloride, KF*2H2O / acetonitrile; dimethylformamide / 48 h / 48 °C
7: 18 percent / Na2CO3 / dimethylformamide / 2.5 h / Ambient temperature
With
pyridine; potassium fluoride; diethyl cyanophosphonate; tetrabutyl-ammonium chloride; hydrogen; sodium carbonate; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; benzene;
DOI:10.1021/jm00371a009
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / Cs2CO2 / dimethylformamide / 60 h / Ambient temperature
2: 92 percent / H2 / 5percent Pd/C / propan-2-ol / 1520 - 2280 Torr / Ambient temperature
3: 100 percent / DCC, pyridine / acetonitrile; dimethylformamide / 1 h / 0 °C
4: 100 percent / benzene / 1 h / Heating
5: 1.) diethyl phosphorocyanidate, Et3N / 1.) DMF, 80 deg C, 2 min, 2.) DMF, 80 deg C, 2 h
6: 53 percent / tetrabutylammonium chloride, KF*2H2O / acetonitrile; dimethylformamide / 48 h / 48 °C
7: 18 percent / Na2CO3 / dimethylformamide / 2.5 h / Ambient temperature
With
pyridine; potassium fluoride; diethyl cyanophosphonate; tetrabutyl-ammonium chloride; hydrogen; sodium carbonate; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; benzene;
DOI:10.1021/jm00371a009
